Bias of heritability estimates from twin data in presence of errors of zygosity determination

R. Chakraborty

Research output: Contribution to journalArticle

Abstract

Simple heritability estimators of continuous as well as discrete traits from twin data are known to overestimate the degree of genetic determination of the measured traits for several reasons. Errors of zygosity determination will, however, underestimate the true heritability. The bias due to wrong assignment of dizygous twin pairs into monozygous type is evaluated here, and the results indicate that this negative bias has a compensatory effect on the estimate of the degree of genetic determination when other factors of similarity between twin pairs are taken into account. It is shown that when an estimate of zygosity error is available, the bias due to this factor can be evaluated quantitatively, and hence the adjustment for zygosity error can be incorporated in the estimation of the degree of genetic determination of a trait. Although this theory is explicitly developed here for twin studies, the general principle also applies for other types of errors of determining the degree of biological relationships for estimation of heritability, in which case this type of error may be more important than the simple zygosity error.

Original languageEnglish
Pages (from-to)33-42
Number of pages10
JournalInternational Journal of Anthropology
Volume5
Issue number1
DOIs
StatePublished - 1 Mar 1990

Keywords

  • Bias of Heritability
  • Concordance Rates in Twin
  • Error of Twin Zygosity
  • Variance Components

Fingerprint Dive into the research topics of 'Bias of heritability estimates from twin data in presence of errors of zygosity determination'. Together they form a unique fingerprint.

  • Cite this