Behavioral approach to probe altered neurotransmission in autoimmune NZB/BINJ mice: Implications for investigations of cognitive dysfunctions

Konrad C. Retz, Michael J. Forster, Harbans Lal

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Autoimmune NZB/BlNJ mice exhibit deficits in learning and memory that show accelerated appearance with age relative to nonautoimmune mice. NZB/BlNJ mice also exhibit an accelerated age‐dependent increase in brain‐reactive antibodies (BRA). The authors review studies employing neuropharmacological probes to examine whether or not autoimmune NZB/BlNJ mice exhibit abnormalities of neurotransmission that would be consistent with learning and memory deficits. NZB/BINJ mice exhibited abnormal responses when tested for motor activity and hypothermia following cholinomimetics and showed accelerated age‐related changes in sensitivity to diazepam. Overall, the experiments reviewed suggest the presence of altered neurological functions in autoimmune NZB/BINJ mice.

Original languageEnglish
Pages (from-to)275-295
Number of pages21
JournalDrug Development Research
Volume15
Issue number2-3
DOIs
StatePublished - 1988

Keywords

  • C57BL/6J mice
  • C57BL/6Nnia mice
  • NZB/BINJ mice
  • autoimmunity
  • learning/memory dysfunctions
  • neurological dysfunctions

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