Abstract
Oglesby, Rosenberg, Winter: Behavioral and biochemical effects of chronic administration of bromide in the rat. Bromide, a sedative in low doses and a psychotogen in high doses in man, was tested for behavioral and biochemical effects in the rat. The kinetics of bromide excretion following chronic administration were studied in the rat to determine drug regimens necessary to achieve stable, non-lethal levels of blood bromide. When administered daily to animals performing on a variable-interval schedule of positive reinforcement (VI 44), a low dose of bromide increased rates of responding while a high dose depressed response rates. Following withdrawal of the drug after six weeks of administration, response rates returned to previously determined control levels. Chlorpromazine failed to antagonize bromide-induced rate depression. No change in the concentration of norepinephrine or 5-hydroxytryptamine was seen with any dose of bromide studied.
| Original language | English |
|---|---|
| Pages (from-to) | 85-92 |
| Number of pages | 8 |
| Journal | Psychopharmacologia |
| Volume | 32 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1 Mar 1973 |
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Keywords
- Bromide
- Chlorpromazine
- Monoamines
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Behavioral and biochemical effects of chronic administration of bromide in the rat. / Oglesby, Michael; Rosenberg, J.; Winter, J. C.
In: Psychopharmacologia, Vol. 32, No. 1, 01.03.1973, p. 85-92.Research output: Contribution to journal › Article
TY - JOUR
T1 - Behavioral and biochemical effects of chronic administration of bromide in the rat
AU - Oglesby, Michael
AU - Rosenberg, J.
AU - Winter, J. C.
PY - 1973/3/1
Y1 - 1973/3/1
N2 - Oglesby, Rosenberg, Winter: Behavioral and biochemical effects of chronic administration of bromide in the rat. Bromide, a sedative in low doses and a psychotogen in high doses in man, was tested for behavioral and biochemical effects in the rat. The kinetics of bromide excretion following chronic administration were studied in the rat to determine drug regimens necessary to achieve stable, non-lethal levels of blood bromide. When administered daily to animals performing on a variable-interval schedule of positive reinforcement (VI 44), a low dose of bromide increased rates of responding while a high dose depressed response rates. Following withdrawal of the drug after six weeks of administration, response rates returned to previously determined control levels. Chlorpromazine failed to antagonize bromide-induced rate depression. No change in the concentration of norepinephrine or 5-hydroxytryptamine was seen with any dose of bromide studied.
AB - Oglesby, Rosenberg, Winter: Behavioral and biochemical effects of chronic administration of bromide in the rat. Bromide, a sedative in low doses and a psychotogen in high doses in man, was tested for behavioral and biochemical effects in the rat. The kinetics of bromide excretion following chronic administration were studied in the rat to determine drug regimens necessary to achieve stable, non-lethal levels of blood bromide. When administered daily to animals performing on a variable-interval schedule of positive reinforcement (VI 44), a low dose of bromide increased rates of responding while a high dose depressed response rates. Following withdrawal of the drug after six weeks of administration, response rates returned to previously determined control levels. Chlorpromazine failed to antagonize bromide-induced rate depression. No change in the concentration of norepinephrine or 5-hydroxytryptamine was seen with any dose of bromide studied.
KW - Bromide
KW - Chlorpromazine
KW - Monoamines
UR - http://www.scopus.com/inward/record.url?scp=0015880858&partnerID=8YFLogxK
U2 - 10.1007/BF00421710
DO - 10.1007/BF00421710
M3 - Article
C2 - 4743238
AN - SCOPUS:0015880858
VL - 32
SP - 85
EP - 92
JO - Psychopharmacologia
JF - Psychopharmacologia
SN - 0033-3158
IS - 1
ER -