Behavioral and biochemical effects of chronic administration of bromide in the rat

M. W. Oglesby; J. Rosenberg; J. C. Winter

doi:10.1007/BF00421710

Behavioral and biochemical effects of chronic administration of bromide in the rat

M. W. Oglesby, J. Rosenberg, J. C. Winter

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Oglesby, Rosenberg, Winter: Behavioral and biochemical effects of chronic administration of bromide in the rat. Bromide, a sedative in low doses and a psychotogen in high doses in man, was tested for behavioral and biochemical effects in the rat. The kinetics of bromide excretion following chronic administration were studied in the rat to determine drug regimens necessary to achieve stable, non-lethal levels of blood bromide. When administered daily to animals performing on a variable-interval schedule of positive reinforcement (VI 44), a low dose of bromide increased rates of responding while a high dose depressed response rates. Following withdrawal of the drug after six weeks of administration, response rates returned to previously determined control levels. Chlorpromazine failed to antagonize bromide-induced rate depression. No change in the concentration of norepinephrine or 5-hydroxytryptamine was seen with any dose of bromide studied.

Original language	English
Pages (from-to)	85-92
Number of pages	8
Journal	Psychopharmacologia
Volume	32
Issue number	1
DOIs	https://doi.org/10.1007/BF00421710
State	Published - 1 Mar 1973

Keywords

Bromide
Chlorpromazine
Monoamines

Access to Document

10.1007/BF00421710

Cite this

@article{0f371e4e0acc45f1b2320ee961cccf12,

title = "Behavioral and biochemical effects of chronic administration of bromide in the rat",

abstract = "Oglesby, Rosenberg, Winter: Behavioral and biochemical effects of chronic administration of bromide in the rat. Bromide, a sedative in low doses and a psychotogen in high doses in man, was tested for behavioral and biochemical effects in the rat. The kinetics of bromide excretion following chronic administration were studied in the rat to determine drug regimens necessary to achieve stable, non-lethal levels of blood bromide. When administered daily to animals performing on a variable-interval schedule of positive reinforcement (VI 44), a low dose of bromide increased rates of responding while a high dose depressed response rates. Following withdrawal of the drug after six weeks of administration, response rates returned to previously determined control levels. Chlorpromazine failed to antagonize bromide-induced rate depression. No change in the concentration of norepinephrine or 5-hydroxytryptamine was seen with any dose of bromide studied.",

keywords = "Bromide, Chlorpromazine, Monoamines",

author = "Oglesby, {M. W.} and J. Rosenberg and Winter, {J. C.}",

year = "1973",

month = mar,

day = "1",

doi = "10.1007/BF00421710",

language = "English",

volume = "32",

pages = "85--92",

journal = "Psychopharmacologia",

issn = "0033-3158",

publisher = "Springer Verlag",

number = "1",

}

TY - JOUR

T1 - Behavioral and biochemical effects of chronic administration of bromide in the rat

AU - Oglesby, M. W.

AU - Rosenberg, J.

AU - Winter, J. C.

PY - 1973/3/1

Y1 - 1973/3/1

N2 - Oglesby, Rosenberg, Winter: Behavioral and biochemical effects of chronic administration of bromide in the rat. Bromide, a sedative in low doses and a psychotogen in high doses in man, was tested for behavioral and biochemical effects in the rat. The kinetics of bromide excretion following chronic administration were studied in the rat to determine drug regimens necessary to achieve stable, non-lethal levels of blood bromide. When administered daily to animals performing on a variable-interval schedule of positive reinforcement (VI 44), a low dose of bromide increased rates of responding while a high dose depressed response rates. Following withdrawal of the drug after six weeks of administration, response rates returned to previously determined control levels. Chlorpromazine failed to antagonize bromide-induced rate depression. No change in the concentration of norepinephrine or 5-hydroxytryptamine was seen with any dose of bromide studied.

AB - Oglesby, Rosenberg, Winter: Behavioral and biochemical effects of chronic administration of bromide in the rat. Bromide, a sedative in low doses and a psychotogen in high doses in man, was tested for behavioral and biochemical effects in the rat. The kinetics of bromide excretion following chronic administration were studied in the rat to determine drug regimens necessary to achieve stable, non-lethal levels of blood bromide. When administered daily to animals performing on a variable-interval schedule of positive reinforcement (VI 44), a low dose of bromide increased rates of responding while a high dose depressed response rates. Following withdrawal of the drug after six weeks of administration, response rates returned to previously determined control levels. Chlorpromazine failed to antagonize bromide-induced rate depression. No change in the concentration of norepinephrine or 5-hydroxytryptamine was seen with any dose of bromide studied.

KW - Bromide

KW - Chlorpromazine

KW - Monoamines

UR - http://www.scopus.com/inward/record.url?scp=0015880858&partnerID=8YFLogxK

U2 - 10.1007/BF00421710

DO - 10.1007/BF00421710

M3 - Article

C2 - 4743238

AN - SCOPUS:0015880858

VL - 32

SP - 85

EP - 92

JO - Psychopharmacologia

JF - Psychopharmacologia

SN - 0033-3158

IS - 1

ER -

Behavioral and biochemical effects of chronic administration of bromide in the rat

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this