Behavioral and biochemical effects of chronic administration of bromide in the rat

Michael Oglesby, J. Rosenberg, J. C. Winter

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Oglesby, Rosenberg, Winter: Behavioral and biochemical effects of chronic administration of bromide in the rat. Bromide, a sedative in low doses and a psychotogen in high doses in man, was tested for behavioral and biochemical effects in the rat. The kinetics of bromide excretion following chronic administration were studied in the rat to determine drug regimens necessary to achieve stable, non-lethal levels of blood bromide. When administered daily to animals performing on a variable-interval schedule of positive reinforcement (VI 44), a low dose of bromide increased rates of responding while a high dose depressed response rates. Following withdrawal of the drug after six weeks of administration, response rates returned to previously determined control levels. Chlorpromazine failed to antagonize bromide-induced rate depression. No change in the concentration of norepinephrine or 5-hydroxytryptamine was seen with any dose of bromide studied.

Original languageEnglish
Pages (from-to)85-92
Number of pages8
JournalPsychopharmacologia
Volume32
Issue number1
DOIs
StatePublished - 1 Mar 1973

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Bromides
Chlorpromazine
Hypnotics and Sedatives
Pharmaceutical Preparations
Serotonin
Norepinephrine
Appointments and Schedules
Depression

Keywords

  • Bromide
  • Chlorpromazine
  • Monoamines

Cite this

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Behavioral and biochemical effects of chronic administration of bromide in the rat. / Oglesby, Michael; Rosenberg, J.; Winter, J. C.

In: Psychopharmacologia, Vol. 32, No. 1, 01.03.1973, p. 85-92.

Research output: Contribution to journalArticle

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