Baroreflex sensitivity during static exercise in individuals with Down syndrome

Kevin S. Heffernan, Tracy Baynard, Styliani Goulopoulou, Ifigenia Giannopoulou, Scott R. Collier, Arturo Figueroa, Bo Fernhall

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Abstract

Introduction: Individuals with Down syndrome (DS) have altered heart rate (HR) and blood pressure (BP) responses to orthostatic challenges and isometric handgrip (IHG) exercise, suggesting possible alteration in baroreflex sensitivity. Purpose: This study investigated baroreflex sensitivity (BRS) as a potential mechanism contributing to chronotropic incompetence during IHG in persons with DS. Methods: Heart rate and BP were continually recorded in 12 individuals with DS and 10 controls, at rest and during 2 min of IHG, at 30% of maximal voluntary contraction (MVC). Spontaneous BRS was derived via the sequence method. Results: No differences were seen in HR at rest between groups. Systolic BP (SBP) was significantly lower in the DS group at rest (106.1 ± 2.9 vs 116.5 ± 3.9 mm Hg. P < 0.05) and during IHG (123.9 ± 4.6 vs 150.1 ± 5.3 mm Hg, P < 0.001). A significant group-by-task interaction was found for both change in HR and change in SBP with IHG, because of an attenuated HR and SBP response to IHG in participants with DS (P < 0.05). When controlling for resting SBP, the DS group had a lower BRS at rest (16.0 ± 1.7 vs 21.2 ± 4.2 ms·mm Hg-1, P < 0.05) and during IHG (7.8 ± 1.0 vs 12.1 ± 2.6 ms·mm Hg,-1 P < 0.05). Conclusions: Individuals with DS have lower BRS at rest and during IHG than controls and this may be related to their attenuated HR response during perturbation.

Original languageEnglish
Pages (from-to)2026-2031
Number of pages6
JournalMedicine and Science in Sports and Exercise
Volume37
Issue number12
DOIs
StatePublished - 1 Dec 2005

Fingerprint

Baroreflex
Down Syndrome
Heart Rate
Blood Pressure
Exercise

Keywords

  • Blood pressure
  • Chronotropic incompetence
  • Heart rate

Cite this

Heffernan, Kevin S. ; Baynard, Tracy ; Goulopoulou, Styliani ; Giannopoulou, Ifigenia ; Collier, Scott R. ; Figueroa, Arturo ; Fernhall, Bo. / Baroreflex sensitivity during static exercise in individuals with Down syndrome. In: Medicine and Science in Sports and Exercise. 2005 ; Vol. 37, No. 12. pp. 2026-2031.
@article{ea0081e6d6c6474a82ba30ae76db493b,
title = "Baroreflex sensitivity during static exercise in individuals with Down syndrome",
abstract = "Introduction: Individuals with Down syndrome (DS) have altered heart rate (HR) and blood pressure (BP) responses to orthostatic challenges and isometric handgrip (IHG) exercise, suggesting possible alteration in baroreflex sensitivity. Purpose: This study investigated baroreflex sensitivity (BRS) as a potential mechanism contributing to chronotropic incompetence during IHG in persons with DS. Methods: Heart rate and BP were continually recorded in 12 individuals with DS and 10 controls, at rest and during 2 min of IHG, at 30{\%} of maximal voluntary contraction (MVC). Spontaneous BRS was derived via the sequence method. Results: No differences were seen in HR at rest between groups. Systolic BP (SBP) was significantly lower in the DS group at rest (106.1 ± 2.9 vs 116.5 ± 3.9 mm Hg. P < 0.05) and during IHG (123.9 ± 4.6 vs 150.1 ± 5.3 mm Hg, P < 0.001). A significant group-by-task interaction was found for both change in HR and change in SBP with IHG, because of an attenuated HR and SBP response to IHG in participants with DS (P < 0.05). When controlling for resting SBP, the DS group had a lower BRS at rest (16.0 ± 1.7 vs 21.2 ± 4.2 ms·mm Hg-1, P < 0.05) and during IHG (7.8 ± 1.0 vs 12.1 ± 2.6 ms·mm Hg,-1 P < 0.05). Conclusions: Individuals with DS have lower BRS at rest and during IHG than controls and this may be related to their attenuated HR response during perturbation.",
keywords = "Blood pressure, Chronotropic incompetence, Heart rate",
author = "Heffernan, {Kevin S.} and Tracy Baynard and Styliani Goulopoulou and Ifigenia Giannopoulou and Collier, {Scott R.} and Arturo Figueroa and Bo Fernhall",
year = "2005",
month = "12",
day = "1",
doi = "10.1249/01.mss.0000179217.59831.41",
language = "English",
volume = "37",
pages = "2026--2031",
journal = "Medicine and Science in Sports and Exercise",
issn = "0195-9131",
publisher = "Lippincott Williams and Wilkins Ltd.",
number = "12",

}

Heffernan, KS, Baynard, T, Goulopoulou, S, Giannopoulou, I, Collier, SR, Figueroa, A & Fernhall, B 2005, 'Baroreflex sensitivity during static exercise in individuals with Down syndrome', Medicine and Science in Sports and Exercise, vol. 37, no. 12, pp. 2026-2031. https://doi.org/10.1249/01.mss.0000179217.59831.41

Baroreflex sensitivity during static exercise in individuals with Down syndrome. / Heffernan, Kevin S.; Baynard, Tracy; Goulopoulou, Styliani; Giannopoulou, Ifigenia; Collier, Scott R.; Figueroa, Arturo; Fernhall, Bo.

In: Medicine and Science in Sports and Exercise, Vol. 37, No. 12, 01.12.2005, p. 2026-2031.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Baroreflex sensitivity during static exercise in individuals with Down syndrome

AU - Heffernan, Kevin S.

AU - Baynard, Tracy

AU - Goulopoulou, Styliani

AU - Giannopoulou, Ifigenia

AU - Collier, Scott R.

AU - Figueroa, Arturo

AU - Fernhall, Bo

PY - 2005/12/1

Y1 - 2005/12/1

N2 - Introduction: Individuals with Down syndrome (DS) have altered heart rate (HR) and blood pressure (BP) responses to orthostatic challenges and isometric handgrip (IHG) exercise, suggesting possible alteration in baroreflex sensitivity. Purpose: This study investigated baroreflex sensitivity (BRS) as a potential mechanism contributing to chronotropic incompetence during IHG in persons with DS. Methods: Heart rate and BP were continually recorded in 12 individuals with DS and 10 controls, at rest and during 2 min of IHG, at 30% of maximal voluntary contraction (MVC). Spontaneous BRS was derived via the sequence method. Results: No differences were seen in HR at rest between groups. Systolic BP (SBP) was significantly lower in the DS group at rest (106.1 ± 2.9 vs 116.5 ± 3.9 mm Hg. P < 0.05) and during IHG (123.9 ± 4.6 vs 150.1 ± 5.3 mm Hg, P < 0.001). A significant group-by-task interaction was found for both change in HR and change in SBP with IHG, because of an attenuated HR and SBP response to IHG in participants with DS (P < 0.05). When controlling for resting SBP, the DS group had a lower BRS at rest (16.0 ± 1.7 vs 21.2 ± 4.2 ms·mm Hg-1, P < 0.05) and during IHG (7.8 ± 1.0 vs 12.1 ± 2.6 ms·mm Hg,-1 P < 0.05). Conclusions: Individuals with DS have lower BRS at rest and during IHG than controls and this may be related to their attenuated HR response during perturbation.

AB - Introduction: Individuals with Down syndrome (DS) have altered heart rate (HR) and blood pressure (BP) responses to orthostatic challenges and isometric handgrip (IHG) exercise, suggesting possible alteration in baroreflex sensitivity. Purpose: This study investigated baroreflex sensitivity (BRS) as a potential mechanism contributing to chronotropic incompetence during IHG in persons with DS. Methods: Heart rate and BP were continually recorded in 12 individuals with DS and 10 controls, at rest and during 2 min of IHG, at 30% of maximal voluntary contraction (MVC). Spontaneous BRS was derived via the sequence method. Results: No differences were seen in HR at rest between groups. Systolic BP (SBP) was significantly lower in the DS group at rest (106.1 ± 2.9 vs 116.5 ± 3.9 mm Hg. P < 0.05) and during IHG (123.9 ± 4.6 vs 150.1 ± 5.3 mm Hg, P < 0.001). A significant group-by-task interaction was found for both change in HR and change in SBP with IHG, because of an attenuated HR and SBP response to IHG in participants with DS (P < 0.05). When controlling for resting SBP, the DS group had a lower BRS at rest (16.0 ± 1.7 vs 21.2 ± 4.2 ms·mm Hg-1, P < 0.05) and during IHG (7.8 ± 1.0 vs 12.1 ± 2.6 ms·mm Hg,-1 P < 0.05). Conclusions: Individuals with DS have lower BRS at rest and during IHG than controls and this may be related to their attenuated HR response during perturbation.

KW - Blood pressure

KW - Chronotropic incompetence

KW - Heart rate

UR - http://www.scopus.com/inward/record.url?scp=28844460332&partnerID=8YFLogxK

U2 - 10.1249/01.mss.0000179217.59831.41

DO - 10.1249/01.mss.0000179217.59831.41

M3 - Article

VL - 37

SP - 2026

EP - 2031

JO - Medicine and Science in Sports and Exercise

JF - Medicine and Science in Sports and Exercise

SN - 0195-9131

IS - 12

ER -