Baroreflex function in endurance- and static exercise-trained men

M. L. Smith, H. M. Graitzer, D. L. Hudson, P. B. Raven

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

The effect of exercise training mode on reflex cardiovascular control was studied in a cross-sectional design. We examined the cardiovascular responses to progressive incremental phenylephrine (PE) infusion to maximal rates of 120 μg/min and the Δ heart rate/Δ blood pressure responses to lower body negative pressure (LBNP) to -50 Torr in 30 men who were either endurance exercise trained (ET), untrained (UT), or weight trained (WT). During PE infusion, measures of blood pressures, forearm blood flow, heart rate and cardiac output, and calculations of forearm vascular resistance, stroke volume, and peripheral vascular resistance were made at each infusion rate when steady-state blood pressure was attained. No significant differences (P<0.05) in forearm blood flow or resistance were observed between the groups at any dose of PE, suggesting that the vasoconstrictor response was similar among the groups. Regression analyses of heart rate against mean blood pressure during the PE infusion were performed to evaluate baroreflex function. A linear model was used and correlation coefficients ranging from 0.82 to 0.96 were obtained (P<0.05). The slope of the line of best fit for the ET subjects (-0.57) was significantly less (P<0.05) than the slopes obtained for either the UT (-0.91) or WT (-0.88) subjects. In addition, the Δ heart rate/Δ blood pressure measurements obtained during LBNP reflected a similarly significant attenuation of reflex chronotropic control in the ET subjects. These data suggested that reflex control of blood pressure during extended alterations in steady-state blood pressure of 5-40 min was suppressed in the ET subjects but not in the WT subjects. Furthermore, we conclude that the endurance training suppression of blood pressure regulation would prove detrimental to the maintenance of blood pressure during acute alterations in posture.

Original languageEnglish
Pages (from-to)585-591
Number of pages7
JournalJournal of Applied Physiology
Volume64
Issue number2
DOIs
StatePublished - 1988

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