Augmented venoarteriolar response with ageing is associated with morning blood pressure surge

Jeung Ki Yoo, Dan Dan Sun, Rosemary S. Parker, Marcus A. Urey, Steven Anthony Romero, Justin S. Lawley, Satyam Sarma, Wanpen Vongpatanasin, Craig G. Crandall, Qi Fu

Research output: Contribution to journalArticle

Abstract

New Findings: What is the central question of this study? The venoarteriolar response (VAR) contributes substantially to the maintenance of orthostatic tolerance in humans. Despite its importance in haemodynamic homeostasis, the impact of ageing on the VAR remains understudied. What is the main finding and its importance? Older adults exhibit an augmented VAR in response to leg dependency. The age-related augmentation of the VAR might be linked with progressive increases of peripheral vascular resistance with ageing. We found a modest but significant correlation between the leg VAR and the morning blood pressure surge in older adults. Augmented leg VAR might contribute to the blood pressure elevation in the early morning. Abstract: The venoarteriolar response (VAR) is a non-adrenergic, non-baroreflex-mediated mechanism of vasoconstriction, which has been proposed to contribute ∼45% of the increase in total peripheral resistance during orthostasis. Despite its importance in human cardiovascular control during orthostatic stress, there is no information available regarding the impact of age and sex on the VAR or its role in diurnal blood pressure (BP) variation. We studied 33 (15 women) young (mean ± SD; 28 ± 4 years old) and 26 (12 women) older (71 ± 3 years old) healthy individuals. Brachial and femoral blood flow were measured using Doppler ultrasound. The percentage reduction in vascular conductance (blood flow/mean BP) during 4 min of limb dependency (35–40 cm below the heart level) was used to assess the VAR. The morning surge in BP was assessed using 24 h ambulatory BP monitoring. Peak VAR in the lower limb, but not in the upper limb, was significantly higher in the older than the younger adults (33 ± 4 versus 26 ± 6%, older versus young; P < 0.05). There was no sex difference in the VAR in either the young or the older group. A greater leg VAR was related to a greater morning surge in BP in older adults (r = −0.4, P = 0.02) but not in the young adults (r = −0.26, P = 0.1). Thus, advancing age enhances the VAR in the lower limb and is associated with the morning blood pressure surge in older adults. Sex does not affect this local axonal reflex in healthy humans.

Original languageEnglish
Pages (from-to)1448-1455
Number of pages8
JournalExperimental physiology
Volume103
Issue number11
DOIs
StatePublished - 1 Nov 2018

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Blood Pressure
Leg
Vascular Resistance
Young Adult
Lower Extremity
Doppler Ultrasonography
Ambulatory Blood Pressure Monitoring
Dizziness
Thigh
Vasoconstriction
Upper Extremity
Sex Characteristics
Blood Vessels
Reflex
Arm
Homeostasis
Extremities
Hemodynamics
Maintenance

Keywords

  • ageing
  • morning blood pressure surge
  • venoarteriolar response

Cite this

Yoo, J. K., Sun, D. D., Parker, R. S., Urey, M. A., Romero, S. A., Lawley, J. S., ... Fu, Q. (2018). Augmented venoarteriolar response with ageing is associated with morning blood pressure surge. Experimental physiology, 103(11), 1448-1455. https://doi.org/10.1113/EP087166
Yoo, Jeung Ki ; Sun, Dan Dan ; Parker, Rosemary S. ; Urey, Marcus A. ; Romero, Steven Anthony ; Lawley, Justin S. ; Sarma, Satyam ; Vongpatanasin, Wanpen ; Crandall, Craig G. ; Fu, Qi. / Augmented venoarteriolar response with ageing is associated with morning blood pressure surge. In: Experimental physiology. 2018 ; Vol. 103, No. 11. pp. 1448-1455.
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Yoo, JK, Sun, DD, Parker, RS, Urey, MA, Romero, SA, Lawley, JS, Sarma, S, Vongpatanasin, W, Crandall, CG & Fu, Q 2018, 'Augmented venoarteriolar response with ageing is associated with morning blood pressure surge', Experimental physiology, vol. 103, no. 11, pp. 1448-1455. https://doi.org/10.1113/EP087166

Augmented venoarteriolar response with ageing is associated with morning blood pressure surge. / Yoo, Jeung Ki; Sun, Dan Dan; Parker, Rosemary S.; Urey, Marcus A.; Romero, Steven Anthony; Lawley, Justin S.; Sarma, Satyam; Vongpatanasin, Wanpen; Crandall, Craig G.; Fu, Qi.

In: Experimental physiology, Vol. 103, No. 11, 01.11.2018, p. 1448-1455.

Research output: Contribution to journalArticle

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AU - Yoo, Jeung Ki

AU - Sun, Dan Dan

AU - Parker, Rosemary S.

AU - Urey, Marcus A.

AU - Romero, Steven Anthony

AU - Lawley, Justin S.

AU - Sarma, Satyam

AU - Vongpatanasin, Wanpen

AU - Crandall, Craig G.

AU - Fu, Qi

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