Abstract
We investigated 98 melanoma patients and 135 normal controls for differences in phenotype and genotype frequencies at the properdin factor B locus. A significant negative association with the Bf-F allele and melanoma was found, resulting in an estimated relative risk of 0.5. The estimated relative risk for developing melanoma among people with the Bf-FF genotype is 0.07. The Bf-S phenotype was significantly increased among the melanoma sample, with an estimated risk of 6.5. The data suggest association of the Bf locus with a melanoma protection and/or susceptibility gene(s).
Original language | English |
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Pages (from-to) | 247-251 |
Number of pages | 5 |
Journal | Cancer Genetics and Cytogenetics |
Volume | 5 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1982 |