Associations of properdin factor B with melanoma

Bruce Budowle; Bruce O. Barger; Charles M. Balch; Rodney C.P. Go; Jeffrey M. Roseman; Ronald T. Acton

doi:10.1016/0165-4608(82)90031-0

Associations of properdin factor B with melanoma

Bruce Budowle, Bruce O. Barger, Charles M. Balch, Rodney C.P. Go, Jeffrey M. Roseman, Ronald T. Acton

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated 98 melanoma patients and 135 normal controls for differences in phenotype and genotype frequencies at the properdin factor B locus. A significant negative association with the Bf-F allele and melanoma was found, resulting in an estimated relative risk of 0.5. The estimated relative risk for developing melanoma among people with the Bf-FF genotype is 0.07. The Bf-S phenotype was significantly increased among the melanoma sample, with an estimated risk of 6.5. The data suggest association of the Bf locus with a melanoma protection and/or susceptibility gene(s).

Original language	English
Pages (from-to)	247-251
Number of pages	5
Journal	Cancer Genetics and Cytogenetics
Volume	5
Issue number	3
DOIs	https://doi.org/10.1016/0165-4608(82)90031-0
State	Published - Mar 1982

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title = "Associations of properdin factor B with melanoma",

abstract = "We investigated 98 melanoma patients and 135 normal controls for differences in phenotype and genotype frequencies at the properdin factor B locus. A significant negative association with the Bf-F allele and melanoma was found, resulting in an estimated relative risk of 0.5. The estimated relative risk for developing melanoma among people with the Bf-FF genotype is 0.07. The Bf-S phenotype was significantly increased among the melanoma sample, with an estimated risk of 6.5. The data suggest association of the Bf locus with a melanoma protection and/or susceptibility gene(s).",

author = "Bruce Budowle and Barger, {Bruce O.} and Balch, {Charles M.} and Go, {Rodney C.P.} and Roseman, {Jeffrey M.} and Acton, {Ronald T.}",

note = "Funding Information: This work was supported by grants from the National Cancer Institute, CA-09128, CA-27197, CA-18609, and CA-13148.",

year = "1982",

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AU - Budowle, Bruce

AU - Barger, Bruce O.

AU - Balch, Charles M.

AU - Go, Rodney C.P.

AU - Roseman, Jeffrey M.

AU - Acton, Ronald T.

N1 - Funding Information: This work was supported by grants from the National Cancer Institute, CA-09128, CA-27197, CA-18609, and CA-13148.

PY - 1982/3

Y1 - 1982/3

N2 - We investigated 98 melanoma patients and 135 normal controls for differences in phenotype and genotype frequencies at the properdin factor B locus. A significant negative association with the Bf-F allele and melanoma was found, resulting in an estimated relative risk of 0.5. The estimated relative risk for developing melanoma among people with the Bf-FF genotype is 0.07. The Bf-S phenotype was significantly increased among the melanoma sample, with an estimated risk of 6.5. The data suggest association of the Bf locus with a melanoma protection and/or susceptibility gene(s).

AB - We investigated 98 melanoma patients and 135 normal controls for differences in phenotype and genotype frequencies at the properdin factor B locus. A significant negative association with the Bf-F allele and melanoma was found, resulting in an estimated relative risk of 0.5. The estimated relative risk for developing melanoma among people with the Bf-FF genotype is 0.07. The Bf-S phenotype was significantly increased among the melanoma sample, with an estimated risk of 6.5. The data suggest association of the Bf locus with a melanoma protection and/or susceptibility gene(s).

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VL - 5

SP - 247

EP - 251

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

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ER -

Associations of properdin factor B with melanoma

Abstract

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