TY - JOUR
T1 - Association of periodontitis and human papillomavirus in oral rinse specimens
T2 - Results from the National Health and Nutrition Survey 2009-2012
AU - Wiener, R. Constance
AU - Sambamoorthi, Usha
AU - Jurevic, Richard J.
N1 - Publisher Copyright:
© 2015 American Dental Association.
PY - 2015/6/1
Y1 - 2015/6/1
N2 - Abstract Background Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinomas are increasing in incidence and are becoming significant public health concerns. Periodontitis is a chronic condition in which the affected tissue may facilitate oral HPV infection and persistence. The purpose of this study was to determine if an association of the presence of HPV in oral rinse specimens and periodontal disease exists. Methods The authors combined the National Health and Nutrition Examination Survey (NHANES) data for years 2009-2010 and 2011-2012. The authors included participants aged 30-69 years who had clinically assessed periodontal and HPV data (n = 6,004). The authors analyzed the data using the Rao-Scott χ2 test and logistic regression. Results There were 498 participants who had the presence of HPV in oral rinse specimens. The adjusted odds ratio for the presence of HPV in oral rinse specimens with relation to periodontal disease was 1.04 (95% confidence interval, 0.63-1.73), adjusting for sex, race and ethnicity, education, age, income-to-poverty ratio, smoking, alcohol use, and number of sex partners during their lifetime. Conclusions The authors failed to reject the hypothesis of no association of the presence of HPV in oral rinse specimens and periodontitis. Practical Implications Although oral HPV infection is a serious concern, the authors found that periodontitis was not shown to be related to the presence of HPV in oral rinse specimens in adjusted analyses in this study.
AB - Abstract Background Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinomas are increasing in incidence and are becoming significant public health concerns. Periodontitis is a chronic condition in which the affected tissue may facilitate oral HPV infection and persistence. The purpose of this study was to determine if an association of the presence of HPV in oral rinse specimens and periodontal disease exists. Methods The authors combined the National Health and Nutrition Examination Survey (NHANES) data for years 2009-2010 and 2011-2012. The authors included participants aged 30-69 years who had clinically assessed periodontal and HPV data (n = 6,004). The authors analyzed the data using the Rao-Scott χ2 test and logistic regression. Results There were 498 participants who had the presence of HPV in oral rinse specimens. The adjusted odds ratio for the presence of HPV in oral rinse specimens with relation to periodontal disease was 1.04 (95% confidence interval, 0.63-1.73), adjusting for sex, race and ethnicity, education, age, income-to-poverty ratio, smoking, alcohol use, and number of sex partners during their lifetime. Conclusions The authors failed to reject the hypothesis of no association of the presence of HPV in oral rinse specimens and periodontitis. Practical Implications Although oral HPV infection is a serious concern, the authors found that periodontitis was not shown to be related to the presence of HPV in oral rinse specimens in adjusted analyses in this study.
KW - National Health and Nutrition Examination Survey
KW - Periodontal diseases
KW - public health and community dentistry
KW - risk assessment
UR - http://www.scopus.com/inward/record.url?scp=84930080725&partnerID=8YFLogxK
U2 - 10.1016/j.adaj.2015.01.019
DO - 10.1016/j.adaj.2015.01.019
M3 - Article
C2 - 26025825
AN - SCOPUS:84930080725
SN - 0002-8177
VL - 146
SP - 382
EP - 389
JO - Journal of the American Dental Association (1939)
JF - Journal of the American Dental Association (1939)
IS - 6
M1 - 81
ER -