TY - JOUR
T1 - Association of osteoarthritis and pain with Alzheimer's Diseases and Related Dementias among older adults in the United States
AU - Ikram, M.
AU - Innes, K.
AU - Sambamoorthi, U.
N1 - Funding Information:
Research reported in this publication was supported in part by the National Institute of General Medical Sciences of the National Institutes of Health under Award Number 2U54GM104942-02 , WVCTSI and in part by the Alzheimer’s Research and Prevention Foundation (ARPF) . The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the ARPF.
Funding Information:
Research reported in this publication was supported in part by the National Institute of General Medical Sciences of the National Institutes of Health under Award Number 2U54GM104942-02, WVCTSI and in part by the Alzheimer's Research and Prevention Foundation (ARPF). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the ARPF.
Publisher Copyright:
© 2019 Osteoarthritis Research Society International
PY - 2019/10
Y1 - 2019/10
N2 - Background: Emerging evidence suggests that Pain Interference (PI) and certain chronic pain conditions, including Osteoarthritis (OA) may be associated with risk for Alzheimer's disease and Related Dementias (ADRD). However, research exploring the relation of OA and PI to ADRD remains sparse. Objective: To assess the association of OA and PI to ADRD using cross-sectional data from a representative sample of USA adults aged ≥65 years. Design: Retrospective cross-sectional. Study sample: Older adults (age ≥ 65 years) drawn from the Medical Expenditure Panel Survey (MEPS, 2009–2015). Methods: OA was identified using both medical conditions files and participant responses to arthritis-specific queries. ADRD was ascertained using the medical conditions files. PI was defined as reported frequent PI with normal activities (PIA). OA and PIA were categorized as a composite variable: 1) OA with PIA; 2) OA without PIA; 3) No OA with PIA; and 4) No OA and no PIA (reference group). Adjusted associations of OA and PIA to ADRD were assessed using logistic regression and adjusted for biological, demographic, socio-economic, lifestyle, and health conditions. Results: Overall, 27.1% had OA, of whom 47.6 % reported PIA vs 31.1% of those without OA; 2.8% had diagnosed ADRD. Adults with PIA either with or without OA had significantly higher odds of ADRD relative to those without OA or PIA (Adjusted odd ratios (AOR's) = 1.37, 95%CI – 1.01, 1.86 (p = 0.04) and 1.44, 95%CI – 1.13, 1.82 (p = 0.003), respectively). Conclusion: PIA in both the presence and absence of OA remained significantly and positively associated with ADRD after adjustment for multiple confounders.
AB - Background: Emerging evidence suggests that Pain Interference (PI) and certain chronic pain conditions, including Osteoarthritis (OA) may be associated with risk for Alzheimer's disease and Related Dementias (ADRD). However, research exploring the relation of OA and PI to ADRD remains sparse. Objective: To assess the association of OA and PI to ADRD using cross-sectional data from a representative sample of USA adults aged ≥65 years. Design: Retrospective cross-sectional. Study sample: Older adults (age ≥ 65 years) drawn from the Medical Expenditure Panel Survey (MEPS, 2009–2015). Methods: OA was identified using both medical conditions files and participant responses to arthritis-specific queries. ADRD was ascertained using the medical conditions files. PI was defined as reported frequent PI with normal activities (PIA). OA and PIA were categorized as a composite variable: 1) OA with PIA; 2) OA without PIA; 3) No OA with PIA; and 4) No OA and no PIA (reference group). Adjusted associations of OA and PIA to ADRD were assessed using logistic regression and adjusted for biological, demographic, socio-economic, lifestyle, and health conditions. Results: Overall, 27.1% had OA, of whom 47.6 % reported PIA vs 31.1% of those without OA; 2.8% had diagnosed ADRD. Adults with PIA either with or without OA had significantly higher odds of ADRD relative to those without OA or PIA (Adjusted odd ratios (AOR's) = 1.37, 95%CI – 1.01, 1.86 (p = 0.04) and 1.44, 95%CI – 1.13, 1.82 (p = 0.003), respectively). Conclusion: PIA in both the presence and absence of OA remained significantly and positively associated with ADRD after adjustment for multiple confounders.
KW - Alzheimer's disease and related dementias
KW - Dementia
KW - Elderly patients
KW - Osteoarthritis
KW - Pain
KW - Pain interference
UR - http://www.scopus.com/inward/record.url?scp=85068084067&partnerID=8YFLogxK
U2 - 10.1016/j.joca.2019.05.021
DO - 10.1016/j.joca.2019.05.021
M3 - Article
C2 - 31200005
AN - SCOPUS:85068084067
SN - 1063-4584
VL - 27
SP - 1470
EP - 1480
JO - Osteoarthritis and Cartilage
JF - Osteoarthritis and Cartilage
IS - 10
ER -