Association of cardiovascular risk factors and blood biomarkers with cognition: The HABS-HD study

The Health and Aging Brain Study (HABS-HD) Study Team

doi:10.1002/dad2.12394

Association of cardiovascular risk factors and blood biomarkers with cognition: The HABS-HD study

The Health and Aging Brain Study (HABS-HD) Study Team

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction: To determine if cardiovascular risk factor (CVRF) burden is associated with Alzheimer's disease (AD) biomarkers and whether they synergistically associate with cognition. Methods: We cross-sectionally studied 1521 non-demented Mexican American (52%) and non-Hispanic White individuals aged ≥50 years. A composite score was calculated by averaging the z-scores of five cognitive tests. Plasma β-amyloid (Aβ) 42/40, total tau (t-tau), and neurofilament light (NfL) were assayed using Simoa. CVRF burden was assessed using the Framingham Risk Score (FRS). Results: Compared to low FRS (< 10% risk), high FRS (≥ 20% risk) was independently associated with increased t-tau and NfL. High FRS was significantly associated with higher NfL only among Mexican American individuals. Intermediate or high FRS (vs. low FRS) were independently associated with lower cognition, and the association remained significant after adjusting for plasma biomarkers. Hypertension synergistically interacted with t-tau and NfL (p < 0.05). Discussion: CVRFs play critical roles, both through independent and neurodegenerative pathways, on cognition.

Original language	English
Article number	e12394
Journal	Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume	15
Issue number	1
DOIs	https://doi.org/10.1002/dad2.12394
State	Published - 1 Jan 2023

Keywords

Hispanic
Mexican American
amyloid
blood biomarkers
cardiovascular risk factors
cognition
neurofilament light
tau

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10.1002/dad2.12394

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@article{a441f8b0b6ef4e56b07ef8115ba60677,

title = "Association of cardiovascular risk factors and blood biomarkers with cognition: The HABS-HD study",

abstract = "Introduction: To determine if cardiovascular risk factor (CVRF) burden is associated with Alzheimer's disease (AD) biomarkers and whether they synergistically associate with cognition. Methods: We cross-sectionally studied 1521 non-demented Mexican American (52%) and non-Hispanic White individuals aged ≥50 years. A composite score was calculated by averaging the z-scores of five cognitive tests. Plasma β-amyloid (Aβ) 42/40, total tau (t-tau), and neurofilament light (NfL) were assayed using Simoa. CVRF burden was assessed using the Framingham Risk Score (FRS). Results: Compared to low FRS (< 10% risk), high FRS (≥ 20% risk) was independently associated with increased t-tau and NfL. High FRS was significantly associated with higher NfL only among Mexican American individuals. Intermediate or high FRS (vs. low FRS) were independently associated with lower cognition, and the association remained significant after adjusting for plasma biomarkers. Hypertension synergistically interacted with t-tau and NfL (p < 0.05). Discussion: CVRFs play critical roles, both through independent and neurodegenerative pathways, on cognition.",

keywords = "Hispanic, Mexican American, amyloid, blood biomarkers, cardiovascular risk factors, cognition, neurofilament light, tau",

author = "{The Health and Aging Brain Study (HABS-HD) Study Team} and Xiaqing Jiang and O'Bryant, {Sid E.} and Johnson, {Leigh A.} and Rissman, {Robert A.} and Kristine Yaffe",

note = "Funding Information: Research reported on this publication was supported by the National Institute on Aging of the National Institutes of Health under Award Numbers R01AG054073, R01AG058533, P41EB015922, U19AG078109, and R35AG071916. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: {\textcopyright} 2022 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.",

year = "2023",

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doi = "10.1002/dad2.12394",

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volume = "15",

journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",

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T1 - Association of cardiovascular risk factors and blood biomarkers with cognition

T2 - The HABS-HD study

AU - The Health and Aging Brain Study (HABS-HD) Study Team

AU - Jiang, Xiaqing

AU - O'Bryant, Sid E.

AU - Johnson, Leigh A.

AU - Rissman, Robert A.

AU - Yaffe, Kristine

N1 - Funding Information: Research reported on this publication was supported by the National Institute on Aging of the National Institutes of Health under Award Numbers R01AG054073, R01AG058533, P41EB015922, U19AG078109, and R35AG071916. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: © 2022 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.

PY - 2023/1/1

Y1 - 2023/1/1

N2 - Introduction: To determine if cardiovascular risk factor (CVRF) burden is associated with Alzheimer's disease (AD) biomarkers and whether they synergistically associate with cognition. Methods: We cross-sectionally studied 1521 non-demented Mexican American (52%) and non-Hispanic White individuals aged ≥50 years. A composite score was calculated by averaging the z-scores of five cognitive tests. Plasma β-amyloid (Aβ) 42/40, total tau (t-tau), and neurofilament light (NfL) were assayed using Simoa. CVRF burden was assessed using the Framingham Risk Score (FRS). Results: Compared to low FRS (< 10% risk), high FRS (≥ 20% risk) was independently associated with increased t-tau and NfL. High FRS was significantly associated with higher NfL only among Mexican American individuals. Intermediate or high FRS (vs. low FRS) were independently associated with lower cognition, and the association remained significant after adjusting for plasma biomarkers. Hypertension synergistically interacted with t-tau and NfL (p < 0.05). Discussion: CVRFs play critical roles, both through independent and neurodegenerative pathways, on cognition.

AB - Introduction: To determine if cardiovascular risk factor (CVRF) burden is associated with Alzheimer's disease (AD) biomarkers and whether they synergistically associate with cognition. Methods: We cross-sectionally studied 1521 non-demented Mexican American (52%) and non-Hispanic White individuals aged ≥50 years. A composite score was calculated by averaging the z-scores of five cognitive tests. Plasma β-amyloid (Aβ) 42/40, total tau (t-tau), and neurofilament light (NfL) were assayed using Simoa. CVRF burden was assessed using the Framingham Risk Score (FRS). Results: Compared to low FRS (< 10% risk), high FRS (≥ 20% risk) was independently associated with increased t-tau and NfL. High FRS was significantly associated with higher NfL only among Mexican American individuals. Intermediate or high FRS (vs. low FRS) were independently associated with lower cognition, and the association remained significant after adjusting for plasma biomarkers. Hypertension synergistically interacted with t-tau and NfL (p < 0.05). Discussion: CVRFs play critical roles, both through independent and neurodegenerative pathways, on cognition.

KW - Hispanic

KW - Mexican American

KW - amyloid

KW - blood biomarkers

KW - cardiovascular risk factors

KW - cognition

KW - neurofilament light

KW - tau

UR - http://www.scopus.com/inward/record.url?scp=85152543708&partnerID=8YFLogxK

U2 - 10.1002/dad2.12394

DO - 10.1002/dad2.12394

M3 - Article

AN - SCOPUS:85152543708

SN - 2352-8729

VL - 15

JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

IS - 1

M1 - e12394

ER -

Association of cardiovascular risk factors and blood biomarkers with cognition: The HABS-HD study

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