Association between genetic variation at the porphobilinogen deaminase gene and schizophrenia

Alan R. Sanders, Diego E. Rincon-Limas, Ranajit Chakraborty, Bernard Grandchamp, Joseph D. Hamilton, William E. Fann, Pragna I. Patel

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

There is growing evidence that some genetic predisposition is important in the etiology of schizophrenia. We have sought to implicate a major gene by performing a candidate gene association study comparing the allele frequencies of seven restriction fragment length polymorphisms (RFLPs) at six loci in both a psychiatrically normal control group (N = 51) and an affected (schizophrenia or schizoaffective disorder) group (N = 55). Each group comprised Caucasians of northern European origin. The candidate areas (D5S39, D5S78, dopamine receptor D2 (DRD2), D11S29, porphobilinogen deaminase (PBGD), and D11S84) were selected on the basis of prior cytogenetic findings in schizophrenics, linkage studies, and/or implicated gene products. The presence of a polymorphic ApaLI site within the PBGD gene showed a significant association with the presence of illness (P = 0.02). The relative risk of possessing the allele with the ApaLI site was 2.10. No significant association was found with any of the six other RFLPs. Our data suggests that either the PBGD gene itself or an unknown gene linked to and/or in linkage disequilibrium with the PBGD locus predisposes some individuals to schizophrenia. Independent replication of these findings will be required to determine their relevance to schizophrenia.

Original languageEnglish
Pages (from-to)211-221
Number of pages11
JournalSchizophrenia Research
Volume8
Issue number3
DOIs
StatePublished - Jan 1993
Externally publishedYes

Keywords

  • (Schizophrenia)
  • Association
  • Linkage
  • Porphobilinogen deaminase gene

Fingerprint Dive into the research topics of 'Association between genetic variation at the porphobilinogen deaminase gene and schizophrenia'. Together they form a unique fingerprint.

  • Cite this

    Sanders, A. R., Rincon-Limas, D. E., Chakraborty, R., Grandchamp, B., Hamilton, J. D., Fann, W. E., & Patel, P. I. (1993). Association between genetic variation at the porphobilinogen deaminase gene and schizophrenia. Schizophrenia Research, 8(3), 211-221. https://doi.org/10.1016/0920-9964(93)90019-F