TY - JOUR
T1 - Association between chronic hepatitis B infection and metabolic syndrome
AU - Zhao, Xiaohui
AU - Shah, Drishti
AU - Sambamoorthi, Usha
N1 - Funding Information:
Conflict of interest The project was partially supported by the National Institute of General Medical Sciences, U54GM104942. Xiaohui Zhao, Drishti Shah, and Usha Sambamoorthi have received research grants from Regeneron Pharmaceuticals, Inc. and Teva Pharmaceutical Industries Ltd. However, the authors have no significant relationships with or financial interests in any commercial companies related to this study or article.
Publisher Copyright:
© 2018, Springer Nature Switzerland AG.
PY - 2018/12/31
Y1 - 2018/12/31
N2 - Purpose: The association between chronic hepatitis B (CHB) infection and metabolic syndrome (MetS) remains inconclusive. This study was designed to determine the association between CHB infection and MetS among the US population with updated data and adjustments for a comprehensive set of risk factors. Methods: Adults aged 18 years or older who were clinically assessed for Hepatitis B and MetS from the National Health and Nutrition Examination Survey (NHANES) 2003–2004, 2005–2006, 2007–2008, 2009–2010, 2011–2012, and 2013–2014 cycles were included in the study (N = 53,392,666). MetS was defined according to the NCEP/ATP III guideline. CHB was identified by the seropositivity of Hepatitis B surface antigen and core antibody in the absence of Hepatitis B surface antibody. Rao-Scott χ 2 test and logistic regressions were employed in the analyses. Results: MetS was less prevalent among adults with CHB compared to adults without CHB (12.1% vs. 18.8%, p = 0.073). In adjusted analyses, adults with CHB were 48% less likely to have MetS compared to those without CHB (95% Confidence Interval [CI]: 0.29–0.94). Regarding individual component of MetS, CHB was inversely associated with high waist circumference (AOR = 0.32, 95% CI: 0.21–0.49) and hypoalphalipoproteinemia (AOR = 0.48, 95% CI: 0.25–0.91). No association between CHB and other metabolic components were found. Conclusions: CHB was inversely associated with MetS, high waist circumference, and hypoalphalipoproteinemia. No significant association was found between CHB and other MetS components.
AB - Purpose: The association between chronic hepatitis B (CHB) infection and metabolic syndrome (MetS) remains inconclusive. This study was designed to determine the association between CHB infection and MetS among the US population with updated data and adjustments for a comprehensive set of risk factors. Methods: Adults aged 18 years or older who were clinically assessed for Hepatitis B and MetS from the National Health and Nutrition Examination Survey (NHANES) 2003–2004, 2005–2006, 2007–2008, 2009–2010, 2011–2012, and 2013–2014 cycles were included in the study (N = 53,392,666). MetS was defined according to the NCEP/ATP III guideline. CHB was identified by the seropositivity of Hepatitis B surface antigen and core antibody in the absence of Hepatitis B surface antibody. Rao-Scott χ 2 test and logistic regressions were employed in the analyses. Results: MetS was less prevalent among adults with CHB compared to adults without CHB (12.1% vs. 18.8%, p = 0.073). In adjusted analyses, adults with CHB were 48% less likely to have MetS compared to those without CHB (95% Confidence Interval [CI]: 0.29–0.94). Regarding individual component of MetS, CHB was inversely associated with high waist circumference (AOR = 0.32, 95% CI: 0.21–0.49) and hypoalphalipoproteinemia (AOR = 0.48, 95% CI: 0.25–0.91). No association between CHB and other metabolic components were found. Conclusions: CHB was inversely associated with MetS, high waist circumference, and hypoalphalipoproteinemia. No significant association was found between CHB and other MetS components.
KW - Chronic hepatitis B infection
KW - High waist circumference
KW - Hypoalphalipoproteinemia
KW - Metabolic syndrome
KW - NHANES
UR - http://www.scopus.com/inward/record.url?scp=85055871307&partnerID=8YFLogxK
U2 - 10.1007/s40200-018-0364-4
DO - 10.1007/s40200-018-0364-4
M3 - Article
AN - SCOPUS:85055871307
SN - 2251-6581
VL - 17
SP - 223
EP - 232
JO - Journal of Diabetes and Metabolic Disorders
JF - Journal of Diabetes and Metabolic Disorders
IS - 2
ER -