Assessment of the severity of Ebola virus disease in Sierra Leone in 2014-2015

J. Y. Wong; W. Zhang; D. Kargbo; U. Haque; W. Hu; P. Wu; A. Kamara; Y. Chen; B. Kargbo; G. E. Glass; R. Yang; B. J. Cowling; C. Liu

doi:10.1017/S0950268815003003

Assessment of the severity of Ebola virus disease in Sierra Leone in 2014-2015

J. Y. Wong, W. Zhang, D. Kargbo, U. Haque, W. Hu, P. Wu, A. Kamara, Y. Chen, B. Kargbo, G. E. Glass, R. Yang, B. J. Cowling, C. Liu

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17 Scopus citations

Abstract

The current Ebola virus disease (EVD) epidemic in West Africa is unprecedented in scale, and Sierra Leone is the most severely affected country. The case fatality risk (CFR) and hospitalization fatality risk (HFR) were used to characterize the severity of infections in confirmed and probable EVD cases in Sierra Leone. Proportional hazards regression models were used to investigate factors associated with the risk of death in EVD cases. In total, there were 17 318 EVD cases reported in Sierra Leone from 23 May 2014 to 31 January 2015. Of the probable and confirmed EVD cases with a reported final outcome, a total of 2536 deaths and 886 recoveries were reported. CFR and HFR estimates were 74·2% [95% credibility interval (CrI) 72·6-75·5] and 68·9% (95% CrI 66·2-71·6), respectively. Risks of death were higher in the youngest (0-4 years) and oldest (60 years) age groups, and in the calendar month of October 2014. Sex and occupational status did not significantly affect the mortality of EVD. The CFR and HFR estimates of EVD were very high in Sierra Leone.

Original language	English
Pages (from-to)	1473-1481
Number of pages	9
Journal	Epidemiology and Infection
Volume	144
Issue number	7
DOIs	https://doi.org/10.1017/S0950268815003003
State	Published - 1 May 2016

Keywords

Death
Ebola virus
severity

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10.1017/S0950268815003003

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title = "Assessment of the severity of Ebola virus disease in Sierra Leone in 2014-2015",

abstract = "The current Ebola virus disease (EVD) epidemic in West Africa is unprecedented in scale, and Sierra Leone is the most severely affected country. The case fatality risk (CFR) and hospitalization fatality risk (HFR) were used to characterize the severity of infections in confirmed and probable EVD cases in Sierra Leone. Proportional hazards regression models were used to investigate factors associated with the risk of death in EVD cases. In total, there were 17 318 EVD cases reported in Sierra Leone from 23 May 2014 to 31 January 2015. Of the probable and confirmed EVD cases with a reported final outcome, a total of 2536 deaths and 886 recoveries were reported. CFR and HFR estimates were 74·2% [95% credibility interval (CrI) 72·6-75·5] and 68·9% (95% CrI 66·2-71·6), respectively. Risks of death were higher in the youngest (0-4 years) and oldest (60 years) age groups, and in the calendar month of October 2014. Sex and occupational status did not significantly affect the mortality of EVD. The CFR and HFR estimates of EVD were very high in Sierra Leone.",

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author = "Wong, {J. Y.} and W. Zhang and D. Kargbo and U. Haque and W. Hu and P. Wu and A. Kamara and Y. Chen and B. Kargbo and Glass, {G. E.} and R. Yang and Cowling, {B. J.} and C. Liu",

note = "Funding Information: J.Y.W., P.W. and B.J.C.were supported by the Harvard Center for Communicable Disease Dynamics from the National Institute of General Medical Sciences (grant no. U54 GM 088558), the Health and Medical Research Fund, Food and Health Bureau, Government of the Hong Kong Special Administrative Region (grant no. 14131432), and a commissioned grant from the Health and Medical Research Fund from the Government of the Hong Kong Special Administrative Region. R.Y. was funded by the National Natural Science Foundation of China (grant no. 81550001). Publisher Copyright: Copyright {\textcopyright} Cambridge University Press 2015.",

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T1 - Assessment of the severity of Ebola virus disease in Sierra Leone in 2014-2015

AU - Wong, J. Y.

AU - Zhang, W.

AU - Kargbo, D.

AU - Haque, U.

AU - Hu, W.

AU - Wu, P.

AU - Kamara, A.

AU - Chen, Y.

AU - Kargbo, B.

AU - Glass, G. E.

AU - Yang, R.

AU - Cowling, B. J.

AU - Liu, C.

N1 - Funding Information: J.Y.W., P.W. and B.J.C.were supported by the Harvard Center for Communicable Disease Dynamics from the National Institute of General Medical Sciences (grant no. U54 GM 088558), the Health and Medical Research Fund, Food and Health Bureau, Government of the Hong Kong Special Administrative Region (grant no. 14131432), and a commissioned grant from the Health and Medical Research Fund from the Government of the Hong Kong Special Administrative Region. R.Y. was funded by the National Natural Science Foundation of China (grant no. 81550001). Publisher Copyright: Copyright © Cambridge University Press 2015.

PY - 2016/5/1

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N2 - The current Ebola virus disease (EVD) epidemic in West Africa is unprecedented in scale, and Sierra Leone is the most severely affected country. The case fatality risk (CFR) and hospitalization fatality risk (HFR) were used to characterize the severity of infections in confirmed and probable EVD cases in Sierra Leone. Proportional hazards regression models were used to investigate factors associated with the risk of death in EVD cases. In total, there were 17 318 EVD cases reported in Sierra Leone from 23 May 2014 to 31 January 2015. Of the probable and confirmed EVD cases with a reported final outcome, a total of 2536 deaths and 886 recoveries were reported. CFR and HFR estimates were 74·2% [95% credibility interval (CrI) 72·6-75·5] and 68·9% (95% CrI 66·2-71·6), respectively. Risks of death were higher in the youngest (0-4 years) and oldest (60 years) age groups, and in the calendar month of October 2014. Sex and occupational status did not significantly affect the mortality of EVD. The CFR and HFR estimates of EVD were very high in Sierra Leone.

AB - The current Ebola virus disease (EVD) epidemic in West Africa is unprecedented in scale, and Sierra Leone is the most severely affected country. The case fatality risk (CFR) and hospitalization fatality risk (HFR) were used to characterize the severity of infections in confirmed and probable EVD cases in Sierra Leone. Proportional hazards regression models were used to investigate factors associated with the risk of death in EVD cases. In total, there were 17 318 EVD cases reported in Sierra Leone from 23 May 2014 to 31 January 2015. Of the probable and confirmed EVD cases with a reported final outcome, a total of 2536 deaths and 886 recoveries were reported. CFR and HFR estimates were 74·2% [95% credibility interval (CrI) 72·6-75·5] and 68·9% (95% CrI 66·2-71·6), respectively. Risks of death were higher in the youngest (0-4 years) and oldest (60 years) age groups, and in the calendar month of October 2014. Sex and occupational status did not significantly affect the mortality of EVD. The CFR and HFR estimates of EVD were very high in Sierra Leone.

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JO - Epidemiology and Infection

JF - Epidemiology and Infection

IS - 7

ER -

Assessment of the severity of Ebola virus disease in Sierra Leone in 2014-2015

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Keywords

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