TY - JOUR
T1 - Assessment of cerebral autoregulation
T2 - The quandary of quantification
AU - Tzeng, Y. C.
AU - Ainslie, P. N.
AU - Cooke, W. H.
AU - Peebles, K. C.
AU - Willie, C. K.
AU - MacRae, B. A.
AU - Smirl, J. D.
AU - Horsman, H. M.
AU - Rickards, C. A.
PY - 2012/9/15
Y1 - 2012/9/15
N2 - We assessed the convergent validity of commonly applied metrics of cerebral autoregulation (CA) to determine the extent to which the metrics can be used interchangeably. To examine between-subject relationships among low-frequency (LF; 0.07-0.2 Hz) and very-low-frequency (VLF; 0.02-0.07 Hz) transfer function coherence, phase, gain, and normalized gain, we performed retrospective transfer function analysis on spontaneous blood pressure and middle cerebral artery blood velocity recordings from 105 individuals. We characterized the relationships (n = 29) among spontaneous transfer function metrics and the rate of regulation index and autoregulatory index derived from bilateral thigh-cuff deflation tests. In addition, we analyzed data from subjects (n = 29) who underwent a repeated squat-to-stand protocol to determine the relationships between transfer function metrics during forced blood pressure fluctuations. Finally, data from subjects (n = 16) who underwent step changes in end-tidal Pco2 (PetCO2) were analyzed to determine whether transfer function metrics could reliably track the modulation of CA within individuals. CA metrics were generally unrelated or showed only weak to moderate correlations. Changes in PetCO2 were positively related to coherence [LF: β = 0.0065 arbitrary units (AU)/mmHg and VLF: β = 0.011 AU/mmHg, both P < 0.01] and inversely related to phase (LF: β = -0.026 rad/mmHg and VLF: β = -0.018 rad/mmHg, both P < 0.01) and normalized gain (LF: β = -0.042%/mmHg2 and VLF: β = -0.013%/mmHg2, both P < 0.01). However, PetCO2 was positively associated with gain (LF: β = 0.0070 cm·s-1·mmHg-2, P < 0.05; and VLF: β = 0.014 cm·s-1·mmHg-2, P < 0.01). Thus, during changes in PetCO2, LF phase was inversely related to LF gain (β = -0.29 cm·s-1·mmHg-1·rad-1, P < 0.01) but positively related to LF normalized gain (β = 1.3% mmHg-1/rad, P < 0.01). These findings collectively suggest that only select CA metrics can be used interchangeably and that interpretation of these measures should be done cautiously,
AB - We assessed the convergent validity of commonly applied metrics of cerebral autoregulation (CA) to determine the extent to which the metrics can be used interchangeably. To examine between-subject relationships among low-frequency (LF; 0.07-0.2 Hz) and very-low-frequency (VLF; 0.02-0.07 Hz) transfer function coherence, phase, gain, and normalized gain, we performed retrospective transfer function analysis on spontaneous blood pressure and middle cerebral artery blood velocity recordings from 105 individuals. We characterized the relationships (n = 29) among spontaneous transfer function metrics and the rate of regulation index and autoregulatory index derived from bilateral thigh-cuff deflation tests. In addition, we analyzed data from subjects (n = 29) who underwent a repeated squat-to-stand protocol to determine the relationships between transfer function metrics during forced blood pressure fluctuations. Finally, data from subjects (n = 16) who underwent step changes in end-tidal Pco2 (PetCO2) were analyzed to determine whether transfer function metrics could reliably track the modulation of CA within individuals. CA metrics were generally unrelated or showed only weak to moderate correlations. Changes in PetCO2 were positively related to coherence [LF: β = 0.0065 arbitrary units (AU)/mmHg and VLF: β = 0.011 AU/mmHg, both P < 0.01] and inversely related to phase (LF: β = -0.026 rad/mmHg and VLF: β = -0.018 rad/mmHg, both P < 0.01) and normalized gain (LF: β = -0.042%/mmHg2 and VLF: β = -0.013%/mmHg2, both P < 0.01). However, PetCO2 was positively associated with gain (LF: β = 0.0070 cm·s-1·mmHg-2, P < 0.05; and VLF: β = 0.014 cm·s-1·mmHg-2, P < 0.01). Thus, during changes in PetCO2, LF phase was inversely related to LF gain (β = -0.29 cm·s-1·mmHg-1·rad-1, P < 0.01) but positively related to LF normalized gain (β = 1.3% mmHg-1/rad, P < 0.01). These findings collectively suggest that only select CA metrics can be used interchangeably and that interpretation of these measures should be done cautiously,
KW - Autoregulation
KW - Blood vessel
KW - Cerebral blood flow
KW - Circulation
UR - http://www.scopus.com/inward/record.url?scp=84866366515&partnerID=8YFLogxK
U2 - 10.1152/ajpheart.00328.2012
DO - 10.1152/ajpheart.00328.2012
M3 - Article
C2 - 22821992
AN - SCOPUS:84866366515
SN - 0363-6135
VL - 303
SP - H658-H671
JO - American Journal of Physiology - Heart and Circulatory Physiology
JF - American Journal of Physiology - Heart and Circulatory Physiology
IS - 6
ER -