TY - JOUR
T1 - Arsenic exposure, AS3MT polymorphism, and neuropsychological functioning among rural dwelling adults and elders
T2 - A cross-sectional study
AU - Edwards, Melissa
AU - Hall, James
AU - Gong, Gordon
AU - O'Bryant, Sid E.
N1 - Funding Information:
Research reported in this publication was supported by the National Institutes of Health under Award Numbers R01AG039389, & L60MD001849. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This research was also funded in part by grants from the Hogg Foundation for Mental Health (JRG-040 & JRG-149) and the Environmental Protection Agency (RD834794). Additional funding was provided by the Texas Tech University Health Sciences Center F. Marie Hall Institute for Rural and Community Health, Garrison Institute on Aging, Laura W. Bush Institute for Women’s Health, and Department of Neurology. The authors would like to thank the entire research team from Project FRONTIER with special thanks to the people of Cochran, Parmer, and Bailey County as well as the Advisory Boards. An additional thank you would like to be extended to Cochran County Memorial Hospital, Parmer County Hospital, Parmer County Rural Health Clinic and their staff for all of their assistance and provision of office space. This work would not have been possible without the assistance of the community recruiters, Lousinda Agnuiano, Bennie O’Brien, and Rosemary McCallum.
Publisher Copyright:
© 2014 Edwards et al.; licensee BioMed Central Ltd.
PY - 2014/3/12
Y1 - 2014/3/12
N2 - Background: The aim was to examine the link between low-level arsenic exposure and cognitive functioning, and the potential role of a single nucleotide polymorphism (SNP A35991G, rs10748835) of the AS3MT gene in modifying this link. Methods: Data were analyzed on 526 participants from Project FRONTIER. Hierarchical linear regressions were created with neuropsychological raw index scores as the outcome variable and arsenic exposure and AS3MT SNP as different predictor variables. Results: Within the total sample, arsenic exposure was negatively associated with language (p∈<∈0.001) and executive functioning (p∈<∈0.001). Among those with the AA genotype of the AS3MT gene, arsenic levels were negatively associated with language (p∈<∈0.001), attention (p∈=∈0.01), and executive functioning (p∈=∈0.04). Among those with the AG genotype, arsenic levels were positively associated with immediate (p∈=∈0.04) and delayed memory (p∈<∈0.001) and negatively associated with executive functioning (p∈=∈0.03). Among those with the GG genotype, arsenic levels were negatively associated with visuospatial functioning (p∈=∈0.02). Conclusions: Low-level arsenic exposure is associated with cognitive functioning; however, this association is modified by an AS3MT gene.
AB - Background: The aim was to examine the link between low-level arsenic exposure and cognitive functioning, and the potential role of a single nucleotide polymorphism (SNP A35991G, rs10748835) of the AS3MT gene in modifying this link. Methods: Data were analyzed on 526 participants from Project FRONTIER. Hierarchical linear regressions were created with neuropsychological raw index scores as the outcome variable and arsenic exposure and AS3MT SNP as different predictor variables. Results: Within the total sample, arsenic exposure was negatively associated with language (p∈<∈0.001) and executive functioning (p∈<∈0.001). Among those with the AA genotype of the AS3MT gene, arsenic levels were negatively associated with language (p∈<∈0.001), attention (p∈=∈0.01), and executive functioning (p∈=∈0.04). Among those with the AG genotype, arsenic levels were positively associated with immediate (p∈=∈0.04) and delayed memory (p∈<∈0.001) and negatively associated with executive functioning (p∈=∈0.03). Among those with the GG genotype, arsenic levels were negatively associated with visuospatial functioning (p∈=∈0.02). Conclusions: Low-level arsenic exposure is associated with cognitive functioning; however, this association is modified by an AS3MT gene.
KW - AS3MT
KW - Arsenic
KW - Cognition
KW - Neuropsychology
UR - http://www.scopus.com/inward/record.url?scp=84926481920&partnerID=8YFLogxK
U2 - 10.1186/1476-069X-13-15
DO - 10.1186/1476-069X-13-15
M3 - Article
C2 - 24621105
AN - SCOPUS:84926481920
SN - 1476-069X
VL - 13
JO - Environmental Health: A Global Access Science Source
JF - Environmental Health: A Global Access Science Source
IS - 1
M1 - 15
ER -