Many questions remain in the study of the normal aqueous outflow pathway and understanding of what is altered in POAG. One of the goals of the conference was to identify future areas of study that will improve our understanding of aqueous humor outflow. These questions have been summarized in Table 1. Finally, suggestions were made that the role of ARVO in research could be expanded in developing a consensus on terminology and techniques. "Giant vacuoles" of Schlemm's canal endothelium are not truly intracytoplasmic vacuoles, and the term and concept was initially confusing to the outside scientists at the conference. An ARVO consensus committee could resolve such issues. Similarly, should a consensus be reached on standard culture conditions for trabecular or Schlemm's canal cells? At present the comparisons of results from different laboratories can be difficult because of differences in culture media, serum supplements, and other culture conditions.