TY - JOUR
T1 - Application of Structural Retinal Biomarkers to Detect Cognitive Impairment in a Primary Care Setting
AU - Mozdbar, Sima
AU - Petersen, Melissa
AU - Zhang, Fan
AU - Johnson, Leigh
AU - Tolman, Alex
AU - Nyalakonda, Ramyashree
AU - Gutierrez, Alejandra
AU - O'Bryant, Sid
N1 - Funding Information:
ACKNOWLEDGMENTS This work would not be possible without the support of the Institute of Translational Research at the University of North Texas Health Science Center. FUNDING Research reported in this publication was supported by the National Institute of Aging (NIA) of the National Institutes of Health under Award Number R01AG058537. This study was also funded by the NIA under Award Number U24AG065204, through the Clinician-Scientists Transdisciplinary Aging Research (Clin-STAR) pilot grant, as well as funding from intramural seed grants from the University of North Texas Health Science Center Department of Pharmacology & Neuroscience. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Funding Information:
Research reported in this publication was supported by the National Institute of Aging (NIA) of the National Institutes of Health under Award Number R01AG058537. This study was also funded by the NIA under Award Number U24AG065204, through the Clinician-Scientists Transdisciplinary Aging Research (Clin-STAR) pilot grant, as well as funding from intramural seed grants from the University of North Texas Health Science Center Department of Pharmacology & Neuroscience. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Publisher Copyright:
© 2022 - The authors. Published by IOS Press.
PY - 2022
Y1 - 2022
N2 - Background: Despite the diagnostic accuracy of advanced neurodiagnostic procedures, the detection of Alzheimer's disease (AD) remains poor in primary care. There is an urgent need for screening tools to aid in the detection of early AD. Objective: This study examines the predictive ability of structural retinal biomarkers in detecting cognitive impairment in a primary care setting. Methods: Participants were recruited from Alzheimer's Disease in Primary Care (ADPC) study. As part of the ADPC Retinal Biomarker Study (ADPC RBS), visual acuity, an ocular history questionnaire, eye pressure, optical coherence tomography (OCT) imaging, and fundus imaging was performed. Results: Data were examined on n = 91 participants. The top biomarkers for predicting cognitive impairment included the inferior quadrant of the outer retinal layers, all four quadrants of the peripapillary retinal nerve fiber layer, and the inferior quadrant of the macular retinal nerve fiber layer. Conclusion: The current data provides strong support for continued investigation into structural retinal biomarkers, particularly the retinal nerve fiber layer, as screening tools for AD.
AB - Background: Despite the diagnostic accuracy of advanced neurodiagnostic procedures, the detection of Alzheimer's disease (AD) remains poor in primary care. There is an urgent need for screening tools to aid in the detection of early AD. Objective: This study examines the predictive ability of structural retinal biomarkers in detecting cognitive impairment in a primary care setting. Methods: Participants were recruited from Alzheimer's Disease in Primary Care (ADPC) study. As part of the ADPC Retinal Biomarker Study (ADPC RBS), visual acuity, an ocular history questionnaire, eye pressure, optical coherence tomography (OCT) imaging, and fundus imaging was performed. Results: Data were examined on n = 91 participants. The top biomarkers for predicting cognitive impairment included the inferior quadrant of the outer retinal layers, all four quadrants of the peripapillary retinal nerve fiber layer, and the inferior quadrant of the macular retinal nerve fiber layer. Conclusion: The current data provides strong support for continued investigation into structural retinal biomarkers, particularly the retinal nerve fiber layer, as screening tools for AD.
KW - Alzheimer's disease
KW - cognitive impairment
KW - optical coherence tomography
KW - retinal biomarkers
UR - http://www.scopus.com/inward/record.url?scp=85146168592&partnerID=8YFLogxK
U2 - 10.3233/ADR-220070
DO - 10.3233/ADR-220070
M3 - Article
AN - SCOPUS:85146168592
SN - 2542-4823
VL - 6
SP - 749
EP - 755
JO - Journal of Alzheimer's Disease Reports
JF - Journal of Alzheimer's Disease Reports
IS - 1
ER -