Application of screening experimental designs to assess chromatographic isotope effect upon isotope-coded derivatization for quantitative liquid chromatography-mass spectrometry

Keyphrases

• Isotope-coded Derivatization 100%
• Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS) 100%
• Isotope Effect 100%
• 15N Labeling 60%
• 2,4-Dinitrophenylhydrazine 40%
• Chromatographic Parameters 40%
• 13C Labeling 40%
• Statistical Evaluation 20%
• 4-hydroxynonenal (4-HNE) 20%
• Comprehensive Assessment 20%
• Biologically Relevant 20%
• Retention Time 20%
• Chromatographic Separation 20%
• Reversed-phase HPLC 20%
• Electrospray Ionization 20%
• 4-Oxo-2-nonenal 20%
• Derivatizing Reagent 20%
• Deuterium Labeling 20%
• Isotopic Labeling 20%
• Deuterium 20%
• Organic Solvents 20%
• Plackett-Burman 20%
• Mobile Phase pH 20%
• Factor Screening 20%
• Aldehydes 20%
• Reactive Aldehydes 20%
• Isotopologues 20%
• Effective Approach 20%
• Matrix Effect 20%
• 15N2 20%
• Acrolein 20%
• Malondialdehyde 20%
• Assay Protocol 20%
• Stationary Phase 20%
• Biological Matrices 20%

Chemistry

• Liquid Chromatography Mass Spectrometry (LCMS) 100%
• Derivatization 100%
• Isotope Effect 100%
• 2,4-dinitrophenylhydrazine 40%
• Reverse Phase Liquid Chromatography 20%
• Acrolein 20%
• Retention Time 20%
• Mobile Phase Composition 20%
• Electrospray Ionization 20%
• Chromatography 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Nitrogen 15 100%
• 2,4 Dinitrophenylhydrazine 66%
• Carbon 13 66%
• Deuterium 66%
• 4 Hydroxynonenal 33%
• Electrospray Ionization 33%
• Acrolein 33%
• Malonaldehyde 33%