Anxiogenic aspects of diazepam withdrawal can be detected in animals

Michael Emmett-Oglesby; David Spencer; Marilyn Lewis; Fatma Elmesallamy; Harbans Lal

doi:10.1016/0014-2999(83)90117-6

Anxiogenic aspects of diazepam withdrawal can be detected in animals

Michael Emmett-Oglesby, David Spencer, Marilyn Lewis, Fatma Elmesallamy, Harbans Lal

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Animals can be trained to discriminate the presence of pentylenetetrazol, and this discrimination has previously been proposed as an animal bioassay for anxiogenicity. In rats made dependent on diazepam, pentylenetetrazol-like stimuli occured during spontaneous or precipitated (with RO 15-1788) withdrawal; these stimuli were blocked by pentobarbital. These results demonstrate that the pentylenetetrazol-based animal model of anxiety can be used to objectively quantify a subjective aspect of benzodiazepine dependence/withdrawal.

Original language	English
Pages (from-to)	127-130
Number of pages	4
Journal	European Journal of Pharmacology
Volume	92
Issue number	1-2
DOIs	https://doi.org/10.1016/0014-2999(83)90117-6
State	Published - 19 Aug 1983

Keywords

Anxiety
Dependence
Diazepam
Pentylenetetrazol
RO 15-1788
Withdrawal

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10.1016/0014-2999(83)90117-6

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title = "Anxiogenic aspects of diazepam withdrawal can be detected in animals",

abstract = "Animals can be trained to discriminate the presence of pentylenetetrazol, and this discrimination has previously been proposed as an animal bioassay for anxiogenicity. In rats made dependent on diazepam, pentylenetetrazol-like stimuli occured during spontaneous or precipitated (with RO 15-1788) withdrawal; these stimuli were blocked by pentobarbital. These results demonstrate that the pentylenetetrazol-based animal model of anxiety can be used to objectively quantify a subjective aspect of benzodiazepine dependence/withdrawal.",

keywords = "Anxiety, Dependence, Diazepam, Pentylenetetrazol, RO 15-1788, Withdrawal",

author = "Michael Emmett-Oglesby and David Spencer and Marilyn Lewis and Fatma Elmesallamy and Harbans Lal",

note = "Funding Information: We gratefully acknowledge the gifts of diazepam from Hoffman-LaRoche,N utley, N.J., and of RO 15-1788 from W. Haefely, Hoffman-LaRoche,B asel, Switzerland. This research supported in part by American Osteopathic Association Grant 70460 and by Faculty Research Grants 34910 and 34940.",

year = "1983",

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doi = "10.1016/0014-2999(83)90117-6",

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volume = "92",

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journal = "European Journal of Pharmacology",

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T1 - Anxiogenic aspects of diazepam withdrawal can be detected in animals

AU - Emmett-Oglesby, Michael

AU - Spencer, David

AU - Lewis, Marilyn

AU - Elmesallamy, Fatma

AU - Lal, Harbans

N1 - Funding Information: We gratefully acknowledge the gifts of diazepam from Hoffman-LaRoche,N utley, N.J., and of RO 15-1788 from W. Haefely, Hoffman-LaRoche,B asel, Switzerland. This research supported in part by American Osteopathic Association Grant 70460 and by Faculty Research Grants 34910 and 34940.

PY - 1983/8/19

Y1 - 1983/8/19

N2 - Animals can be trained to discriminate the presence of pentylenetetrazol, and this discrimination has previously been proposed as an animal bioassay for anxiogenicity. In rats made dependent on diazepam, pentylenetetrazol-like stimuli occured during spontaneous or precipitated (with RO 15-1788) withdrawal; these stimuli were blocked by pentobarbital. These results demonstrate that the pentylenetetrazol-based animal model of anxiety can be used to objectively quantify a subjective aspect of benzodiazepine dependence/withdrawal.

AB - Animals can be trained to discriminate the presence of pentylenetetrazol, and this discrimination has previously been proposed as an animal bioassay for anxiogenicity. In rats made dependent on diazepam, pentylenetetrazol-like stimuli occured during spontaneous or precipitated (with RO 15-1788) withdrawal; these stimuli were blocked by pentobarbital. These results demonstrate that the pentylenetetrazol-based animal model of anxiety can be used to objectively quantify a subjective aspect of benzodiazepine dependence/withdrawal.

KW - Anxiety

KW - Dependence

KW - Diazepam

KW - Pentylenetetrazol

KW - RO 15-1788

KW - Withdrawal

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SP - 127

EP - 130

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 1-2

ER -

Anxiogenic aspects of diazepam withdrawal can be detected in animals

Abstract

Keywords

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