Antiretroviral Boosting Agent Cobicistat Increases the Pharmacokinetic Exposure and Anticoagulant Effect of Dabigatran in HIV-Negative Healthy Volunteers

Lori A. Gordon; Parag Kumar; Kristina M. Brooks; Anela Kellogg; Maryellen McManus; Raul M. Alfaro; Khanh Nghiem; Jomy M. George; Jay Lozier; Scott R. Penzak; Colleen Hadigan

doi:10.1161/CIRCULATIONAHA.116.025257

Antiretroviral Boosting Agent Cobicistat Increases the Pharmacokinetic Exposure and Anticoagulant Effect of Dabigatran in HIV-Negative Healthy Volunteers

Lori A. Gordon, Parag Kumar, Kristina M. Brooks, Anela Kellogg, Maryellen McManus, Raul M. Alfaro, Khanh Nghiem, Jomy M. George, Jay Lozier, Scott R. Penzak, Colleen Hadigan

UNT System College of Pharmacy

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Original language	English
Pages (from-to)	1909-1911
Number of pages	3
Journal	Circulation
Volume	134
Issue number	23
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.116.025257
State	Published - 6 Dec 2016

Keywords

anticoagulants
antiretroviral
cobicistat
dabigatran
drug-drug interaction
pharmacodynamics
pharmacokinetics
thrombin time

Access to Document

10.1161/CIRCULATIONAHA.116.025257

Cite this

Gordon, L. A., Kumar, P., Brooks, K. M., Kellogg, A., McManus, M., Alfaro, R. M., Nghiem, K., George, J. M., Lozier, J., Penzak, S. R., & Hadigan, C. (2016). Antiretroviral Boosting Agent Cobicistat Increases the Pharmacokinetic Exposure and Anticoagulant Effect of Dabigatran in HIV-Negative Healthy Volunteers. Circulation, 134(23), 1909-1911. https://doi.org/10.1161/CIRCULATIONAHA.116.025257

Gordon, Lori A. ; Kumar, Parag ; Brooks, Kristina M. ; Kellogg, Anela ; McManus, Maryellen ; Alfaro, Raul M. ; Nghiem, Khanh ; George, Jomy M. ; Lozier, Jay ; Penzak, Scott R. ; Hadigan, Colleen. / Antiretroviral Boosting Agent Cobicistat Increases the Pharmacokinetic Exposure and Anticoagulant Effect of Dabigatran in HIV-Negative Healthy Volunteers. In: Circulation. 2016 ; Vol. 134, No. 23. pp. 1909-1911.

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title = "Antiretroviral Boosting Agent Cobicistat Increases the Pharmacokinetic Exposure and Anticoagulant Effect of Dabigatran in HIV-Negative Healthy Volunteers",

keywords = "anticoagulants, antiretroviral, cobicistat, dabigatran, drug-drug interaction, pharmacodynamics, pharmacokinetics, thrombin time",

author = "Gordon, {Lori A.} and Parag Kumar and Brooks, {Kristina M.} and Anela Kellogg and Maryellen McManus and Alfaro, {Raul M.} and Khanh Nghiem and George, {Jomy M.} and Jay Lozier and Penzak, {Scott R.} and Colleen Hadigan",

year = "2016",

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doi = "10.1161/CIRCULATIONAHA.116.025257",

language = "English",

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pages = "1909--1911",

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Gordon, LA, Kumar, P, Brooks, KM, Kellogg, A, McManus, M, Alfaro, RM, Nghiem, K, George, JM, Lozier, J, Penzak, SR & Hadigan, C 2016, 'Antiretroviral Boosting Agent Cobicistat Increases the Pharmacokinetic Exposure and Anticoagulant Effect of Dabigatran in HIV-Negative Healthy Volunteers', Circulation, vol. 134, no. 23, pp. 1909-1911. https://doi.org/10.1161/CIRCULATIONAHA.116.025257

Antiretroviral Boosting Agent Cobicistat Increases the Pharmacokinetic Exposure and Anticoagulant Effect of Dabigatran in HIV-Negative Healthy Volunteers. / Gordon, Lori A.; Kumar, Parag; Brooks, Kristina M.; Kellogg, Anela; McManus, Maryellen; Alfaro, Raul M.; Nghiem, Khanh; George, Jomy M.; Lozier, Jay; Penzak, Scott R.; Hadigan, Colleen.

In: Circulation, Vol. 134, No. 23, 06.12.2016, p. 1909-1911.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Antiretroviral Boosting Agent Cobicistat Increases the Pharmacokinetic Exposure and Anticoagulant Effect of Dabigatran in HIV-Negative Healthy Volunteers

AU - Gordon, Lori A.

AU - Kumar, Parag

AU - Brooks, Kristina M.

AU - Kellogg, Anela

AU - McManus, Maryellen

AU - Alfaro, Raul M.

AU - Nghiem, Khanh

AU - George, Jomy M.

AU - Lozier, Jay

AU - Penzak, Scott R.

AU - Hadigan, Colleen

PY - 2016/12/6

Y1 - 2016/12/6

KW - anticoagulants

KW - antiretroviral

KW - cobicistat

KW - dabigatran

KW - drug-drug interaction

KW - pharmacodynamics

KW - pharmacokinetics

KW - thrombin time

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U2 - 10.1161/CIRCULATIONAHA.116.025257

DO - 10.1161/CIRCULATIONAHA.116.025257

M3 - Article

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VL - 134

SP - 1909

EP - 1911

JO - Circulation

JF - Circulation

SN - 0009-7322

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