Antimalarial drug resistance in Bangladesh, 1996-2012

Ubydul Haque, Gregory E. Glass, Waziul Haque, Nazrul Islam, Shyamal Roy, Jahirul Karim, Harald Noedl

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Malaria remains an important health problem in Bangladesh, with approximately 14 million people at risk. Antimalarial drug resistance is a major obstacle to the control of malaria in endemic countries. In 2012, Bangladesh reported an estimated 29 522 malaria episodes, of which 94% were reported as being caused by Plasmodium falciparum. In this study, we reviewed and summarized antimalarial drug resistance data from Bangladesh published until June 2013. We searched published sources for data referring to any type of P. falciparum drug resistance (in vivo, in vitro, or molecular) and found 169 articles published in peer-reviewed journals. Of these, 143 articles were excluded because they did not meet our inclusion criteria. After detailed review of the remaining 26 articles, 14 were selected for evaluation. Published studies indicate that P. falciparum shows varying levels of resistance to chloroquine, mefloquine and sulfadoxine-pyrimethamine. Combination therapy of chloroquine and primaquine has proven ineffective and combinations of sulfadoxine-pyrimethamine with either quinine or chloroquine have also shown poor efficacy. Recent studies indicate that artemisinin derivatives, such as artesunate, remain highly efficacious in treating P. falciparum malaria. Available data suggest that artemisinins, quinine, doxycyline, mefloquine-artesunate and azithromycin-artesunate combination therapy remain efficacious in the treatment of P. falciparum malaria in Bangladesh.

Original languageEnglish
Article numbertrt088
Pages (from-to)745-752
Number of pages8
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Issue number12
StatePublished - Dec 2013


  • Bangladesh
  • Drug
  • Malaria
  • Resistance


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