Antiarrhythmic activity of 3‐amino‐3‐methyloxindoles

M. J. Kornet, P. A. Thio, N. Malone, W. C. Lubawy

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

A series of 3‐amino‐3‐methyloxindoles was synthesized from indoles by modification of previously described procedures. All compounds showed activity against chloroform‐induced arrhythmias in mice. One member of the series, 3‐methyl‐3‐piperi‐dinooxindole, displayed activity equal to that of lidocaine while showing only one‐third the acute toxicity.

Original languageEnglish
Pages (from-to)639-642
Number of pages4
JournalJournal of Pharmaceutical Sciences
Volume64
Issue number4
DOIs
StatePublished - Apr 1975

Keywords

  • 3‐Amino‐3‐methyloxindoles—synthesis, antiarrhythmic activity, compared to lidocaine
  • Antiarrhythmic activity—3‐amino‐3‐methyloxindoles synthesized and screened

Fingerprint Dive into the research topics of 'Antiarrhythmic activity of 3‐amino‐3‐methyloxindoles'. Together they form a unique fingerprint.

  • Cite this