Abstract
A series of 3‐amino‐3‐methyloxindoles was synthesized from indoles by modification of previously described procedures. All compounds showed activity against chloroform‐induced arrhythmias in mice. One member of the series, 3‐methyl‐3‐piperi‐dinooxindole, displayed activity equal to that of lidocaine while showing only one‐third the acute toxicity.
| Original language | English |
|---|---|
| Pages (from-to) | 639-642 |
| Number of pages | 4 |
| Journal | Journal of Pharmaceutical Sciences |
| Volume | 64 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1975 |
Keywords
- 3‐Amino‐3‐methyloxindoles—synthesis, antiarrhythmic activity, compared to lidocaine
- Antiarrhythmic activity—3‐amino‐3‐methyloxindoles synthesized and screened
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Cite this
Kornet, M. J., Thio, P. A., Malone, N., & Lubawy, W. C. (1975). Antiarrhythmic activity of 3‐amino‐3‐methyloxindoles. Journal of Pharmaceutical Sciences, 64(4), 639-642. https://doi.org/10.1002/jps.2600640413