Antiarrhythmic activity of 3‐amino‐3‐methyloxindoles

M. J. Kornet, P. A. Thio, N. Malone, W. C. Lubawy

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A series of 3‐amino‐3‐methyloxindoles was synthesized from indoles by modification of previously described procedures. All compounds showed activity against chloroform‐induced arrhythmias in mice. One member of the series, 3‐methyl‐3‐piperi‐dinooxindole, displayed activity equal to that of lidocaine while showing only one‐third the acute toxicity.

Original languageEnglish
Pages (from-to)639-642
Number of pages4
JournalJournal of Pharmaceutical Sciences
Issue number4
StatePublished - Apr 1975


  • 3‐Amino‐3‐methyloxindoles—synthesis, antiarrhythmic activity, compared to lidocaine
  • Antiarrhythmic activity—3‐amino‐3‐methyloxindoles synthesized and screened

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