Animal models of glucocorticoid-induced glaucoma

Darryl R. Overby, Abbot F. Clark

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Glucocorticoid (GC) therapy is widely used to treat a variety of inflammatory diseases and conditions. While unmatched in their anti-inflammatory and immunosuppressive activities, GC therapy is often associated with the significant ocular side effect of GC-induced ocular hypertension (OHT) and iatrogenic open-angle glaucoma. Investigators have generated GC-induced OHT and glaucoma in at least 8 different species besides man. These models mimic many features of this condition in man and provide morphologic and molecular insights into the pathogenesis of GC-OHT. In addition, there are many clinical, morphological, and molecular similarities between GC-induced glaucoma and primary open-angle glaucoma (POAG), making animals models of GC-induced OHT and glaucoma attractive models in which to study specific aspects of POAG.

Original languageEnglish
Pages (from-to)15-22
Number of pages8
JournalExperimental eye research
Volume141
DOIs
StatePublished - 13 Apr 2015

Keywords

  • Glaucoma
  • Glucocorticoid
  • Intraocular pressure
  • Ocular hypertension
  • Steroid glaucoma

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