Abstract
Glucocorticoid (GC) therapy is widely used to treat a variety of inflammatory diseases and conditions. While unmatched in their anti-inflammatory and immunosuppressive activities, GC therapy is often associated with the significant ocular side effect of GC-induced ocular hypertension (OHT) and iatrogenic open-angle glaucoma. Investigators have generated GC-induced OHT and glaucoma in at least 8 different species besides man. These models mimic many features of this condition in man and provide morphologic and molecular insights into the pathogenesis of GC-OHT. In addition, there are many clinical, morphological, and molecular similarities between GC-induced glaucoma and primary open-angle glaucoma (POAG), making animals models of GC-induced OHT and glaucoma attractive models in which to study specific aspects of POAG.
Original language | English |
---|---|
Pages (from-to) | 15-22 |
Number of pages | 8 |
Journal | Experimental eye research |
Volume | 141 |
DOIs | |
State | Published - 13 Apr 2015 |
Keywords
- Glaucoma
- Glucocorticoid
- Intraocular pressure
- Ocular hypertension
- Steroid glaucoma