TY - JOUR
T1 - Analyses of Genetic Structure of Tibeto-Burman Populations Reveals Sex-Biased Admixture in Southern Tibeto-Burmans
AU - Wen, Bo
AU - Xie, Xuanhua
AU - Gao, Song
AU - Li, Hui
AU - Shi, Hong
AU - Song, Xiufeng
AU - Qian, Tingzhi
AU - Xiao, Chunjie
AU - Jin, Jianzhong
AU - Su, Bing
AU - Lu, Daru
AU - Chakraborty, Ranajit
AU - Jin, Li
N1 - Funding Information:
We thank all of the donors for making this work possible. This work is partially supported by Natural Science Foundation of China grant 39993420. L.J. is also supported by National Science Foundation grant BCS-0213857, and L.J. and R.C. are supported by National Institutes of Health grant GM 41399.
PY - 2004/5
Y1 - 2004/5
N2 - An unequal contribution of male and female lineages from parental populations to admixed ones is not uncommon in the American continents, as a consequence of directional gene flow from European men into African and Hispanic Americans in the past several centuries. However, little is known about sex-biased admixture in East Asia, where substantial migrations are recorded. Tibeto-Burman (TB) populations were historically derived from ancient tribes of northwestern China and subsequently moved to the south, where they admixed with the southern natives during the past 2,600 years. They are currently extensively distributed in China and Southeast Asia. In this study, we analyze the variations of 965 Y chromosomes and 754 mtDNAs in >20 TB populations from China. By examining the haplotype group distributions of Y-chromosome and mtDNA markers and their principal components, we show that the genetic structure of the extant southern Tibeto-Burman (STB) populations were primarily formed by two parental groups: northern immigrants and native southerners. Furthermore, the admixture has a bias between male and female lineages, with a stronger influence of northern immigrants on the male lineages (∼62%) and with the southern natives contributing more extensively to the female lineages (∼56%) in the extant STBs. This is the first genetic evidence revealing sex-biased admixture in STB populations, which has genetic, historical, and anthropological implications.
AB - An unequal contribution of male and female lineages from parental populations to admixed ones is not uncommon in the American continents, as a consequence of directional gene flow from European men into African and Hispanic Americans in the past several centuries. However, little is known about sex-biased admixture in East Asia, where substantial migrations are recorded. Tibeto-Burman (TB) populations were historically derived from ancient tribes of northwestern China and subsequently moved to the south, where they admixed with the southern natives during the past 2,600 years. They are currently extensively distributed in China and Southeast Asia. In this study, we analyze the variations of 965 Y chromosomes and 754 mtDNAs in >20 TB populations from China. By examining the haplotype group distributions of Y-chromosome and mtDNA markers and their principal components, we show that the genetic structure of the extant southern Tibeto-Burman (STB) populations were primarily formed by two parental groups: northern immigrants and native southerners. Furthermore, the admixture has a bias between male and female lineages, with a stronger influence of northern immigrants on the male lineages (∼62%) and with the southern natives contributing more extensively to the female lineages (∼56%) in the extant STBs. This is the first genetic evidence revealing sex-biased admixture in STB populations, which has genetic, historical, and anthropological implications.
UR - http://www.scopus.com/inward/record.url?scp=2342459067&partnerID=8YFLogxK
U2 - 10.1086/386292
DO - 10.1086/386292
M3 - Article
C2 - 15042512
AN - SCOPUS:2342459067
SN - 0002-9297
VL - 74
SP - 856
EP - 865
JO - American Journal of Human Genetics
JF - American Journal of Human Genetics
IS - 5
ER -