Analogues of the dopamine D2 receptor antagonist L741,626: Binding, function, and SAR

Peter Grundt, Sarah Little Jane Husband, Robert R. Luedtke, Michelle Taylor, Amy Hauck Newman

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A series of analogues of the dopamine D2 receptor antagonist L741,626 were synthesized and evaluated for binding and function at D2 family receptor subtypes. Several analogues showed comparable binding profiles to the parent ligand, however, in general, chemical modification served to reduce D2 binding affinity and selectivity.

Original languageEnglish
Pages (from-to)745-749
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Issue number3
Publication statusPublished - 1 Feb 2007



  • Dopamine D2 receptor antagonists

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