Analogues of the dopamine D2 receptor antagonist L741,626: Binding, function, and SAR

Peter Grundt, Sarah Little Jane Husband, Robert R. Luedtke, Michelle Taylor, Amy Hauck Newman

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

A series of analogues of the dopamine D2 receptor antagonist L741,626 were synthesized and evaluated for binding and function at D2 family receptor subtypes. Several analogues showed comparable binding profiles to the parent ligand, however, in general, chemical modification served to reduce D2 binding affinity and selectivity.

Original languageEnglish
Pages (from-to)745-749
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number3
DOIs
StatePublished - 1 Feb 2007

Keywords

  • Dopamine D2 receptor antagonists

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