An overview of a biopsychosocial model of epigenetics and pain catastrophizing

Danielle M. Brecht, Robert Joseph Gatchel

Research output: Contribution to journalReview article

Abstract

In an earlier Special Issue in the Journal of Applied Biobehavioral Research (JABR), Gatchel (Journal of Applied Biobehavioral Research, 2017, 22[1], e12088) addressed the construct of pain catastrophizing (PC). The present article is meant to extend those reviews within a biopsychosocial context, as well as update recent research on PC with a specific concentration on genetic factors. An overview of biological factors as they relate to PC and epigenetics are reviewed first (brain areas associated with pain and how they adapt neurochemically to chronic noxious stimuli, polymorphism of various genes, etc.), proceeded by the discussion of psychological (depression, anxiety, and the genomic link to neuroticism) and social influences (reason people engage in PC, age's impact on neuronal restructuring) as they corroborate the argument of PC's link to genetic factors. Finally, this article concludes by providing future directions for research concerning PC such as examining the efficacy of Pain Neurobiology Education, as well as gene therapy.

Original languageEnglish
Article numbere12171
JournalJournal of Applied Biobehavioral Research
Volume24
Issue number3
DOIs
StatePublished - 1 Sep 2019

Fingerprint

Catastrophization
Epigenomics
pain
Research
heredity
Pain
Neurobiology
Biological Factors
gene therapy
Genetic Therapy
biological factors
neuroticism
Anxiety
neurosciences
Depression
PC
Psychology
Education
restructuring
brain

Keywords

  • biopsychosocial
  • chronic illnesses/diseases
  • comorbid physical and mental health disorders
  • genetics/epigenetics
  • health psychology
  • pain

Cite this

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An overview of a biopsychosocial model of epigenetics and pain catastrophizing. / Brecht, Danielle M.; Gatchel, Robert Joseph.

In: Journal of Applied Biobehavioral Research, Vol. 24, No. 3, e12171, 01.09.2019.

Research output: Contribution to journalReview article

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