An investigation of the Plasmodium falciparum malaria epidemic in Kavango and Zambezi regions of Namibia in 2016

Emmanuel Chanda, Mohd Arshad, Asmaa Khaloua, Wenyi Zhang, Josephine Namboze, Pentrina Uusiku, Andreas H. Angula, Khoti Gausi, Desta Tiruneh, Quazi M. Islam, Korine Kolivras, Ubydul Haque

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Background Namibia is one of the countries among the eight that are targeting malaria elimination in southern Africa. However, the country has encountered malaria epidemics in recent years. The objective of this study was to investigate malaria epidemics and to contribute to strengthening malaria surveillance and control in an effort to move Namibia toward eliminating malaria. Method Malaria epidemiology data for 2014-2015 were collected from the weekly surveillance system. All consenting household members within a 100-m radius of index households were screened in 2016 using a Carestart malaria HRP2/pLDH combined rapid diagnostic test after epidemics. All houses within this radius were sprayed in 2016 with the pyrethroid deltamethrin and K-Othrine WG 250. Anopheles mosquito-positive breeding sites were identified and treated with the organophosphate larvicide temephos. Insecticide susceptibility and bioassay tests were conducted. Results During the epidemic response period in 2016, 56 parasitologically confirmed Plasmodium falciparum malaria cases in the Zambezi region were detected from active screening. The majority of those cases (83%) were asymptomatic infections. In the Kavango region, the malaria epidemic persisted, with 228 P. falciparum malaria cases recorded, but only 97 were investigated. In Namibia, malaria vector susceptibility was detected to 4% dichlorodiphenyltrichloroethane. Indoor residual spraying was conducted in 377 (90%) of the targeted households along with community awareness through health education of 1499 people and distribution of more than 2000 information, education and communication materials. The P. falciparum malaria cases in the Zambezi decreased from 122 in week 9 to 97 after week 15. Conclusions Malaria epidemics along with the persistence of asymptomatic reservoir infections pose a serious challenge in Namibia's elimination effort. The country needs to ensure sustainable interventions to target asymptomatic reservoir infections and prevent epidemics in order to successfully achieve its goal of eliminating malaria.

Original languageEnglish
Pages (from-to)546-554
Number of pages9
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume112
Issue number12
DOIs
StatePublished - 1 Dec 2018

Fingerprint

Namibia
Falciparum Malaria
Malaria
Asymptomatic Infections
Temefos
Southern Africa
Pyrethrins
Anopheles
Organophosphates
Insecticides
Culicidae
Health Education
Routine Diagnostic Tests
Biological Assay
Breeding
Epidemiology

Keywords

  • Epidemic
  • Kavango and Zambezi regions
  • Namibia
  • Plasmodium falciparum
  • investigation
  • malaria

Cite this

Chanda, Emmanuel ; Arshad, Mohd ; Khaloua, Asmaa ; Zhang, Wenyi ; Namboze, Josephine ; Uusiku, Pentrina ; Angula, Andreas H. ; Gausi, Khoti ; Tiruneh, Desta ; Islam, Quazi M. ; Kolivras, Korine ; Haque, Ubydul. / An investigation of the Plasmodium falciparum malaria epidemic in Kavango and Zambezi regions of Namibia in 2016. In: Transactions of the Royal Society of Tropical Medicine and Hygiene. 2018 ; Vol. 112, No. 12. pp. 546-554.
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title = "An investigation of the Plasmodium falciparum malaria epidemic in Kavango and Zambezi regions of Namibia in 2016",
abstract = "Background Namibia is one of the countries among the eight that are targeting malaria elimination in southern Africa. However, the country has encountered malaria epidemics in recent years. The objective of this study was to investigate malaria epidemics and to contribute to strengthening malaria surveillance and control in an effort to move Namibia toward eliminating malaria. Method Malaria epidemiology data for 2014-2015 were collected from the weekly surveillance system. All consenting household members within a 100-m radius of index households were screened in 2016 using a Carestart malaria HRP2/pLDH combined rapid diagnostic test after epidemics. All houses within this radius were sprayed in 2016 with the pyrethroid deltamethrin and K-Othrine WG 250. Anopheles mosquito-positive breeding sites were identified and treated with the organophosphate larvicide temephos. Insecticide susceptibility and bioassay tests were conducted. Results During the epidemic response period in 2016, 56 parasitologically confirmed Plasmodium falciparum malaria cases in the Zambezi region were detected from active screening. The majority of those cases (83{\%}) were asymptomatic infections. In the Kavango region, the malaria epidemic persisted, with 228 P. falciparum malaria cases recorded, but only 97 were investigated. In Namibia, malaria vector susceptibility was detected to 4{\%} dichlorodiphenyltrichloroethane. Indoor residual spraying was conducted in 377 (90{\%}) of the targeted households along with community awareness through health education of 1499 people and distribution of more than 2000 information, education and communication materials. The P. falciparum malaria cases in the Zambezi decreased from 122 in week 9 to 97 after week 15. Conclusions Malaria epidemics along with the persistence of asymptomatic reservoir infections pose a serious challenge in Namibia's elimination effort. The country needs to ensure sustainable interventions to target asymptomatic reservoir infections and prevent epidemics in order to successfully achieve its goal of eliminating malaria.",
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author = "Emmanuel Chanda and Mohd Arshad and Asmaa Khaloua and Wenyi Zhang and Josephine Namboze and Pentrina Uusiku and Angula, {Andreas H.} and Khoti Gausi and Desta Tiruneh and Islam, {Quazi M.} and Korine Kolivras and Ubydul Haque",
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Chanda, E, Arshad, M, Khaloua, A, Zhang, W, Namboze, J, Uusiku, P, Angula, AH, Gausi, K, Tiruneh, D, Islam, QM, Kolivras, K & Haque, U 2018, 'An investigation of the Plasmodium falciparum malaria epidemic in Kavango and Zambezi regions of Namibia in 2016', Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 112, no. 12, pp. 546-554. https://doi.org/10.1093/trstmh/try097

An investigation of the Plasmodium falciparum malaria epidemic in Kavango and Zambezi regions of Namibia in 2016. / Chanda, Emmanuel; Arshad, Mohd; Khaloua, Asmaa; Zhang, Wenyi; Namboze, Josephine; Uusiku, Pentrina; Angula, Andreas H.; Gausi, Khoti; Tiruneh, Desta; Islam, Quazi M.; Kolivras, Korine; Haque, Ubydul.

In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 112, No. 12, 01.12.2018, p. 546-554.

Research output: Contribution to journalReview article

TY - JOUR

T1 - An investigation of the Plasmodium falciparum malaria epidemic in Kavango and Zambezi regions of Namibia in 2016

AU - Chanda, Emmanuel

AU - Arshad, Mohd

AU - Khaloua, Asmaa

AU - Zhang, Wenyi

AU - Namboze, Josephine

AU - Uusiku, Pentrina

AU - Angula, Andreas H.

AU - Gausi, Khoti

AU - Tiruneh, Desta

AU - Islam, Quazi M.

AU - Kolivras, Korine

AU - Haque, Ubydul

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Background Namibia is one of the countries among the eight that are targeting malaria elimination in southern Africa. However, the country has encountered malaria epidemics in recent years. The objective of this study was to investigate malaria epidemics and to contribute to strengthening malaria surveillance and control in an effort to move Namibia toward eliminating malaria. Method Malaria epidemiology data for 2014-2015 were collected from the weekly surveillance system. All consenting household members within a 100-m radius of index households were screened in 2016 using a Carestart malaria HRP2/pLDH combined rapid diagnostic test after epidemics. All houses within this radius were sprayed in 2016 with the pyrethroid deltamethrin and K-Othrine WG 250. Anopheles mosquito-positive breeding sites were identified and treated with the organophosphate larvicide temephos. Insecticide susceptibility and bioassay tests were conducted. Results During the epidemic response period in 2016, 56 parasitologically confirmed Plasmodium falciparum malaria cases in the Zambezi region were detected from active screening. The majority of those cases (83%) were asymptomatic infections. In the Kavango region, the malaria epidemic persisted, with 228 P. falciparum malaria cases recorded, but only 97 were investigated. In Namibia, malaria vector susceptibility was detected to 4% dichlorodiphenyltrichloroethane. Indoor residual spraying was conducted in 377 (90%) of the targeted households along with community awareness through health education of 1499 people and distribution of more than 2000 information, education and communication materials. The P. falciparum malaria cases in the Zambezi decreased from 122 in week 9 to 97 after week 15. Conclusions Malaria epidemics along with the persistence of asymptomatic reservoir infections pose a serious challenge in Namibia's elimination effort. The country needs to ensure sustainable interventions to target asymptomatic reservoir infections and prevent epidemics in order to successfully achieve its goal of eliminating malaria.

AB - Background Namibia is one of the countries among the eight that are targeting malaria elimination in southern Africa. However, the country has encountered malaria epidemics in recent years. The objective of this study was to investigate malaria epidemics and to contribute to strengthening malaria surveillance and control in an effort to move Namibia toward eliminating malaria. Method Malaria epidemiology data for 2014-2015 were collected from the weekly surveillance system. All consenting household members within a 100-m radius of index households were screened in 2016 using a Carestart malaria HRP2/pLDH combined rapid diagnostic test after epidemics. All houses within this radius were sprayed in 2016 with the pyrethroid deltamethrin and K-Othrine WG 250. Anopheles mosquito-positive breeding sites were identified and treated with the organophosphate larvicide temephos. Insecticide susceptibility and bioassay tests were conducted. Results During the epidemic response period in 2016, 56 parasitologically confirmed Plasmodium falciparum malaria cases in the Zambezi region were detected from active screening. The majority of those cases (83%) were asymptomatic infections. In the Kavango region, the malaria epidemic persisted, with 228 P. falciparum malaria cases recorded, but only 97 were investigated. In Namibia, malaria vector susceptibility was detected to 4% dichlorodiphenyltrichloroethane. Indoor residual spraying was conducted in 377 (90%) of the targeted households along with community awareness through health education of 1499 people and distribution of more than 2000 information, education and communication materials. The P. falciparum malaria cases in the Zambezi decreased from 122 in week 9 to 97 after week 15. Conclusions Malaria epidemics along with the persistence of asymptomatic reservoir infections pose a serious challenge in Namibia's elimination effort. The country needs to ensure sustainable interventions to target asymptomatic reservoir infections and prevent epidemics in order to successfully achieve its goal of eliminating malaria.

KW - Epidemic

KW - Kavango and Zambezi regions

KW - Namibia

KW - Plasmodium falciparum

KW - investigation

KW - malaria

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U2 - 10.1093/trstmh/try097

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JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

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