Abstract
2B4 (CD244) acts as an activation receptor on human NK cells, whereas it sends inhibitory signals in murine NK cells. A previous study indicated a prominent role for AP-1 in the transcription of 2B4 gene. To further understand the transcriptional regulation we analyzed the upstream positive regulatory region (-1151 to -704) of the 2B4 promoter. We have identified an Ets element that regulates the 2B4 gene transcription in an AP1 dependent manner.
Original language | English |
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Pages (from-to) | 181-185 |
Number of pages | 5 |
Journal | Biochimica et Biophysica Acta - Gene Structure and Expression |
Volume | 1728 |
Issue number | 3 |
DOIs | |
State | Published - 1 May 2005 |
Keywords
- 2B4 promoter
- Natural killer cell
- Transcription regulation