An Ets element regulates the transcription of the human 2B4 gene in natural killer cells

Swapnil V. Vaidya, Porunelloor A. Mathew

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

2B4 (CD244) acts as an activation receptor on human NK cells, whereas it sends inhibitory signals in murine NK cells. A previous study indicated a prominent role for AP-1 in the transcription of 2B4 gene. To further understand the transcriptional regulation we analyzed the upstream positive regulatory region (-1151 to -704) of the 2B4 promoter. We have identified an Ets element that regulates the 2B4 gene transcription in an AP1 dependent manner.

Original languageEnglish
Pages (from-to)181-185
Number of pages5
JournalBiochimica et Biophysica Acta - Gene Structure and Expression
Volume1728
Issue number3
DOIs
StatePublished - 1 May 2005

Keywords

  • 2B4 promoter
  • Natural killer cell
  • Transcription regulation

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