An Ets element regulates the transcription of the human 2B4 gene in natural killer cells

Swapnil V. Vaidya; Porunelloor A. Mathew

doi:10.1016/j.bbaexp.2005.02.002

An Ets element regulates the transcription of the human 2B4 gene in natural killer cells

Swapnil V. Vaidya, Porunelloor A. Mathew

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

2B4 (CD244) acts as an activation receptor on human NK cells, whereas it sends inhibitory signals in murine NK cells. A previous study indicated a prominent role for AP-1 in the transcription of 2B4 gene. To further understand the transcriptional regulation we analyzed the upstream positive regulatory region (-1151 to -704) of the 2B4 promoter. We have identified an Ets element that regulates the 2B4 gene transcription in an AP1 dependent manner.

Original language	English
Pages (from-to)	181-185
Number of pages	5
Journal	Biochimica et Biophysica Acta - Gene Structure and Expression
Volume	1728
Issue number	3
DOIs	https://doi.org/10.1016/j.bbaexp.2005.02.002
State	Published - 1 May 2005

Keywords

2B4 promoter
Natural killer cell
Transcription regulation

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10.1016/j.bbaexp.2005.02.002

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title = "An Ets element regulates the transcription of the human 2B4 gene in natural killer cells",

abstract = "2B4 (CD244) acts as an activation receptor on human NK cells, whereas it sends inhibitory signals in murine NK cells. A previous study indicated a prominent role for AP-1 in the transcription of 2B4 gene. To further understand the transcriptional regulation we analyzed the upstream positive regulatory region (-1151 to -704) of the 2B4 promoter. We have identified an Ets element that regulates the 2B4 gene transcription in an AP1 dependent manner.",

keywords = "2B4 promoter, Natural killer cell, Transcription regulation",

author = "Vaidya, {Swapnil V.} and Mathew, {Porunelloor A.}",

note = "Funding Information: This work was supported by the NIH grant CA85753 to PAM.",

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T1 - An Ets element regulates the transcription of the human 2B4 gene in natural killer cells

AU - Vaidya, Swapnil V.

AU - Mathew, Porunelloor A.

N1 - Funding Information: This work was supported by the NIH grant CA85753 to PAM.

PY - 2005/5/1

Y1 - 2005/5/1

N2 - 2B4 (CD244) acts as an activation receptor on human NK cells, whereas it sends inhibitory signals in murine NK cells. A previous study indicated a prominent role for AP-1 in the transcription of 2B4 gene. To further understand the transcriptional regulation we analyzed the upstream positive regulatory region (-1151 to -704) of the 2B4 promoter. We have identified an Ets element that regulates the 2B4 gene transcription in an AP1 dependent manner.

AB - 2B4 (CD244) acts as an activation receptor on human NK cells, whereas it sends inhibitory signals in murine NK cells. A previous study indicated a prominent role for AP-1 in the transcription of 2B4 gene. To further understand the transcriptional regulation we analyzed the upstream positive regulatory region (-1151 to -704) of the 2B4 promoter. We have identified an Ets element that regulates the 2B4 gene transcription in an AP1 dependent manner.

KW - 2B4 promoter

KW - Natural killer cell

KW - Transcription regulation

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DO - 10.1016/j.bbaexp.2005.02.002

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AN - SCOPUS:18044387623

SN - 0167-4781

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SP - 181

EP - 185

JO - Biochimica et Biophysica Acta - Gene Structure and Expression

JF - Biochimica et Biophysica Acta - Gene Structure and Expression

IS - 3

ER -

An Ets element regulates the transcription of the human 2B4 gene in natural killer cells

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Keywords

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