Abstract
An asymmetric alkylation-ring-closing metathesis strategy was developed for the construction of α,α'-disubstituted medium ring ethers. The approach features an asymmetric alkylation of highly functionalized α-alkoxy acyl oxazolidinones followed by ring closure effected by Grubbs' ruthenium catalyst. The relationship between diene conformation and the rate of ring- closure was examined.
Original language | English |
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Pages (from-to) | 899-903 |
Number of pages | 5 |
Journal | Synthesis |
Issue number | 6 |
DOIs | |
State | Published - 2000 |
Keywords
- Asymmetric-alkylation
- Cyclic ethers
- Gauche effect
- Marine natural products
- Ring-closing metathesis
- Ruthenium