Ambulatory blood pressure patterns in patients with retinal vein occlusion

Vishal N. Rao, J. Niklas Ulrich, Anthony J. Viera, Anna Parlin, Sharon Fekrat, Sai Chavala

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5 Citations (Scopus)

Abstract

Purpose: Failure of blood pressure (BP) to dip during sleep (nondipper pattern) is associated with cardiovascular disease and stroke. The prevalence and degree of nondipping and masked hypertension in patients with retinal vein occlusion (RVO), which is associated with stroke, has not been previously examined. Methods: We measured clinic and 24-hour ambulatory BPs in 22 patients with RVO and 20 control participants without known eye disease matched by age and sex. Mean BP dipping, defined as the ratio of difference in mean awake and sleep systolic BPs to mean awake systolic BP, and masked and nocturnal hypertension were compared between groups. Results: Mean 24-hour ambulatory BP was 144/79 mmHg among those with RVO and 136/77 mmHg among controls. Patients with RVO had an almost 2-fold higher prevalence of nondipping pattern (80.8% [95% confidence interval, 52.8-94.1] vs. 50.4% [95% confidence interval, 26.1-74.5]; P = 0.008). Average sleep systolic BP dip in patients with RVO was 6.1% versus 11.9% in controls (P = 0.004). More patients with RVO had masked hypertension by ambulatory BPs than controls (71% vs. 50%), but this difference was not statistically significant. Conclusion: Our data suggest an association between RVO and nondipper BP pattern. Ambulatory BP monitoring may be useful in the evaluation of patients with RVO by identifying those who may benefit from more aggressive BP control.

Original languageEnglish
Pages (from-to)2304-2310
Number of pages7
JournalRetina
Volume36
Issue number12
DOIs
StatePublished - 1 Dec 2016

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Retinal Vein Occlusion
Blood Pressure
Masked Hypertension
Sleep
Confidence Intervals
Ambulatory Blood Pressure Monitoring
Eye Diseases
Cardiovascular Diseases
Stroke
Myocardial Infarction

Keywords

  • ambulatory blood pressure monitoring
  • cardiovascular disease risk
  • diagnostic tests
  • epidemiology
  • nondipper
  • retinal vein occlusion

Cite this

Rao, V. N., Ulrich, J. N., Viera, A. J., Parlin, A., Fekrat, S., & Chavala, S. (2016). Ambulatory blood pressure patterns in patients with retinal vein occlusion. Retina, 36(12), 2304-2310. https://doi.org/10.1097/IAE.0000000000001071
Rao, Vishal N. ; Ulrich, J. Niklas ; Viera, Anthony J. ; Parlin, Anna ; Fekrat, Sharon ; Chavala, Sai. / Ambulatory blood pressure patterns in patients with retinal vein occlusion. In: Retina. 2016 ; Vol. 36, No. 12. pp. 2304-2310.
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Rao, VN, Ulrich, JN, Viera, AJ, Parlin, A, Fekrat, S & Chavala, S 2016, 'Ambulatory blood pressure patterns in patients with retinal vein occlusion', Retina, vol. 36, no. 12, pp. 2304-2310. https://doi.org/10.1097/IAE.0000000000001071

Ambulatory blood pressure patterns in patients with retinal vein occlusion. / Rao, Vishal N.; Ulrich, J. Niklas; Viera, Anthony J.; Parlin, Anna; Fekrat, Sharon; Chavala, Sai.

In: Retina, Vol. 36, No. 12, 01.12.2016, p. 2304-2310.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Ambulatory blood pressure patterns in patients with retinal vein occlusion

AU - Rao, Vishal N.

AU - Ulrich, J. Niklas

AU - Viera, Anthony J.

AU - Parlin, Anna

AU - Fekrat, Sharon

AU - Chavala, Sai

PY - 2016/12/1

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N2 - Purpose: Failure of blood pressure (BP) to dip during sleep (nondipper pattern) is associated with cardiovascular disease and stroke. The prevalence and degree of nondipping and masked hypertension in patients with retinal vein occlusion (RVO), which is associated with stroke, has not been previously examined. Methods: We measured clinic and 24-hour ambulatory BPs in 22 patients with RVO and 20 control participants without known eye disease matched by age and sex. Mean BP dipping, defined as the ratio of difference in mean awake and sleep systolic BPs to mean awake systolic BP, and masked and nocturnal hypertension were compared between groups. Results: Mean 24-hour ambulatory BP was 144/79 mmHg among those with RVO and 136/77 mmHg among controls. Patients with RVO had an almost 2-fold higher prevalence of nondipping pattern (80.8% [95% confidence interval, 52.8-94.1] vs. 50.4% [95% confidence interval, 26.1-74.5]; P = 0.008). Average sleep systolic BP dip in patients with RVO was 6.1% versus 11.9% in controls (P = 0.004). More patients with RVO had masked hypertension by ambulatory BPs than controls (71% vs. 50%), but this difference was not statistically significant. Conclusion: Our data suggest an association between RVO and nondipper BP pattern. Ambulatory BP monitoring may be useful in the evaluation of patients with RVO by identifying those who may benefit from more aggressive BP control.

AB - Purpose: Failure of blood pressure (BP) to dip during sleep (nondipper pattern) is associated with cardiovascular disease and stroke. The prevalence and degree of nondipping and masked hypertension in patients with retinal vein occlusion (RVO), which is associated with stroke, has not been previously examined. Methods: We measured clinic and 24-hour ambulatory BPs in 22 patients with RVO and 20 control participants without known eye disease matched by age and sex. Mean BP dipping, defined as the ratio of difference in mean awake and sleep systolic BPs to mean awake systolic BP, and masked and nocturnal hypertension were compared between groups. Results: Mean 24-hour ambulatory BP was 144/79 mmHg among those with RVO and 136/77 mmHg among controls. Patients with RVO had an almost 2-fold higher prevalence of nondipping pattern (80.8% [95% confidence interval, 52.8-94.1] vs. 50.4% [95% confidence interval, 26.1-74.5]; P = 0.008). Average sleep systolic BP dip in patients with RVO was 6.1% versus 11.9% in controls (P = 0.004). More patients with RVO had masked hypertension by ambulatory BPs than controls (71% vs. 50%), but this difference was not statistically significant. Conclusion: Our data suggest an association between RVO and nondipper BP pattern. Ambulatory BP monitoring may be useful in the evaluation of patients with RVO by identifying those who may benefit from more aggressive BP control.

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KW - cardiovascular disease risk

KW - diagnostic tests

KW - epidemiology

KW - nondipper

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U2 - 10.1097/IAE.0000000000001071

DO - 10.1097/IAE.0000000000001071

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JO - Retina

JF - Retina

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