Alternative drug therapies for mania: A literature review

M. W. Jann, J. C. Garrelts, L. Ereshefsky, S. R. Saklad

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

This article reviews the agents used to treat manic patients. It has been suggested that up to 20 percent of all manic patients are refractory to lithium. We reviewed studies suggesting that drugs affecting the serotoninergic, adrenergic, dopaminergic, and opioid neurotransmission systems, as well as anticonvulsants and others, are possible alternative treatments. Despite the large number of agents used, few large controlled studies carefully examine these interventions. Clinical assessments using specific manic rating scales are lacking in most studies. Among the successful alternative treatments reported, carbamazepine has received the most intensive research. Other suggested therapeutic agents, such as levothyroxine and clorgyline, require additional research to verify their effectiveness. From these pharmacological approaches and an understanding of pathophysiology of mania, future therapeutic interventions can be formulated.

Original languageEnglish
Pages (from-to)577-589
Number of pages13
JournalDrug Intelligence and Clinical Pharmacy
Volume18
Issue number7-8
DOIs
StatePublished - 1 Jan 1984

Fingerprint

Complementary Therapies
Bipolar Disorder
Drug Therapy
Clorgyline
Carbamazepine
Therapeutics
Thyroxine
Lithium
Research
Synaptic Transmission
Adrenergic Agents
Anticonvulsants
Opioid Analgesics
Pharmacology
Pharmaceutical Preparations

Cite this

Jann, M. W. ; Garrelts, J. C. ; Ereshefsky, L. ; Saklad, S. R. / Alternative drug therapies for mania : A literature review. In: Drug Intelligence and Clinical Pharmacy. 1984 ; Vol. 18, No. 7-8. pp. 577-589.
@article{5dee57d990c94e80abca12a7d620b573,
title = "Alternative drug therapies for mania: A literature review",
abstract = "This article reviews the agents used to treat manic patients. It has been suggested that up to 20 percent of all manic patients are refractory to lithium. We reviewed studies suggesting that drugs affecting the serotoninergic, adrenergic, dopaminergic, and opioid neurotransmission systems, as well as anticonvulsants and others, are possible alternative treatments. Despite the large number of agents used, few large controlled studies carefully examine these interventions. Clinical assessments using specific manic rating scales are lacking in most studies. Among the successful alternative treatments reported, carbamazepine has received the most intensive research. Other suggested therapeutic agents, such as levothyroxine and clorgyline, require additional research to verify their effectiveness. From these pharmacological approaches and an understanding of pathophysiology of mania, future therapeutic interventions can be formulated.",
author = "Jann, {M. W.} and Garrelts, {J. C.} and L. Ereshefsky and Saklad, {S. R.}",
year = "1984",
month = "1",
day = "1",
doi = "10.1177/106002808401800704",
language = "English",
volume = "18",
pages = "577--589",
journal = "Drug Intelligence and Clinical Pharmacy",
issn = "0012-6578",
publisher = "Drug Intelligence and Clinical Pharmacy, Inc.",
number = "7-8",

}

Alternative drug therapies for mania : A literature review. / Jann, M. W.; Garrelts, J. C.; Ereshefsky, L.; Saklad, S. R.

In: Drug Intelligence and Clinical Pharmacy, Vol. 18, No. 7-8, 01.01.1984, p. 577-589.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Alternative drug therapies for mania

T2 - A literature review

AU - Jann, M. W.

AU - Garrelts, J. C.

AU - Ereshefsky, L.

AU - Saklad, S. R.

PY - 1984/1/1

Y1 - 1984/1/1

N2 - This article reviews the agents used to treat manic patients. It has been suggested that up to 20 percent of all manic patients are refractory to lithium. We reviewed studies suggesting that drugs affecting the serotoninergic, adrenergic, dopaminergic, and opioid neurotransmission systems, as well as anticonvulsants and others, are possible alternative treatments. Despite the large number of agents used, few large controlled studies carefully examine these interventions. Clinical assessments using specific manic rating scales are lacking in most studies. Among the successful alternative treatments reported, carbamazepine has received the most intensive research. Other suggested therapeutic agents, such as levothyroxine and clorgyline, require additional research to verify their effectiveness. From these pharmacological approaches and an understanding of pathophysiology of mania, future therapeutic interventions can be formulated.

AB - This article reviews the agents used to treat manic patients. It has been suggested that up to 20 percent of all manic patients are refractory to lithium. We reviewed studies suggesting that drugs affecting the serotoninergic, adrenergic, dopaminergic, and opioid neurotransmission systems, as well as anticonvulsants and others, are possible alternative treatments. Despite the large number of agents used, few large controlled studies carefully examine these interventions. Clinical assessments using specific manic rating scales are lacking in most studies. Among the successful alternative treatments reported, carbamazepine has received the most intensive research. Other suggested therapeutic agents, such as levothyroxine and clorgyline, require additional research to verify their effectiveness. From these pharmacological approaches and an understanding of pathophysiology of mania, future therapeutic interventions can be formulated.

UR - http://www.scopus.com/inward/record.url?scp=0021225530&partnerID=8YFLogxK

U2 - 10.1177/106002808401800704

DO - 10.1177/106002808401800704

M3 - Review article

C2 - 6430658

AN - SCOPUS:0021225530

VL - 18

SP - 577

EP - 589

JO - Drug Intelligence and Clinical Pharmacy

JF - Drug Intelligence and Clinical Pharmacy

SN - 0012-6578

IS - 7-8

ER -