Altered levels of blood proteins in Alzheimer's disease longitudinal study

Results from Australian Imaging Biomarkers Lifestyle Study of Ageing cohort

and the, AIBL Research Group

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Abstract

Introduction A blood-based biomarker panel to identify individuals with preclinical Alzheimer's disease (AD) would be an inexpensive and accessible first step for routine testing. Methods We analyzed 14 biomarkers that have previously been linked to AD in the Australian Imaging Biomarkers lifestyle longitudinal study of aging cohort. Results Levels of apolipoprotein J (apoJ) were higher in AD individuals compared with healthy controls at baseline and 18 months (P =.0003) and chemokine-309 (I-309) were increased in AD patients compared to mild cognitive impaired individuals over 36 months (P =.0008). Discussion These data suggest that apoJ may have potential in the context of use (COU) of AD diagnostics, I-309 may be specifically useful in the COU of identifying individuals at greatest risk for progressing toward AD. This work takes an initial step toward identifying blood biomarkers with potential use in the diagnosis and prognosis of AD and should be validated across other prospective cohorts.

Original languageEnglish
Pages (from-to)60-72
Number of pages13
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume8
DOIs
StatePublished - 1 Jan 2017

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Longitudinal Studies
Life Style
Blood Proteins
Alzheimer Disease
Cohort Studies
Biomarkers
Clusterin
Chemokine CCL1

Keywords

  • Alzheimer's disease
  • Biomarkers
  • Blood

Cite this

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title = "Altered levels of blood proteins in Alzheimer's disease longitudinal study: Results from Australian Imaging Biomarkers Lifestyle Study of Ageing cohort",
abstract = "Introduction A blood-based biomarker panel to identify individuals with preclinical Alzheimer's disease (AD) would be an inexpensive and accessible first step for routine testing. Methods We analyzed 14 biomarkers that have previously been linked to AD in the Australian Imaging Biomarkers lifestyle longitudinal study of aging cohort. Results Levels of apolipoprotein J (apoJ) were higher in AD individuals compared with healthy controls at baseline and 18 months (P =.0003) and chemokine-309 (I-309) were increased in AD patients compared to mild cognitive impaired individuals over 36 months (P =.0008). Discussion These data suggest that apoJ may have potential in the context of use (COU) of AD diagnostics, I-309 may be specifically useful in the COU of identifying individuals at greatest risk for progressing toward AD. This work takes an initial step toward identifying blood biomarkers with potential use in the diagnosis and prognosis of AD and should be validated across other prospective cohorts.",
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Altered levels of blood proteins in Alzheimer's disease longitudinal study : Results from Australian Imaging Biomarkers Lifestyle Study of Ageing cohort. / and the; AIBL Research Group.

In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, Vol. 8, 01.01.2017, p. 60-72.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Hone, Eugene

AU - Pedrini, Steve

AU - Doecke, James

AU - O'Bryant, Sid

AU - James, Ian

AU - O'Bryant, Sidney

AU - Rowe, Christopher C.

AU - Villemagne, Victor L.

AU - Ames, David

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AU - Martins, Ralph N.

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AB - Introduction A blood-based biomarker panel to identify individuals with preclinical Alzheimer's disease (AD) would be an inexpensive and accessible first step for routine testing. Methods We analyzed 14 biomarkers that have previously been linked to AD in the Australian Imaging Biomarkers lifestyle longitudinal study of aging cohort. Results Levels of apolipoprotein J (apoJ) were higher in AD individuals compared with healthy controls at baseline and 18 months (P =.0003) and chemokine-309 (I-309) were increased in AD patients compared to mild cognitive impaired individuals over 36 months (P =.0008). Discussion These data suggest that apoJ may have potential in the context of use (COU) of AD diagnostics, I-309 may be specifically useful in the COU of identifying individuals at greatest risk for progressing toward AD. This work takes an initial step toward identifying blood biomarkers with potential use in the diagnosis and prognosis of AD and should be validated across other prospective cohorts.

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