Alterations to the Intestinal Microbiome and Metabolome of Pimephales promelas and Mus musculus Following Exposure to Dietary Methylmercury

Kristin N. Bridges, Yan Zhang, Thomas E. Curran, Jason T. Magnuson, Barney J. Venables, Katherine E. Durrer, Michael Shane Allen, Aaron P. Roberts

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Abstract

Mercury is a global contaminant, which may be microbially transformed into methylmercury (MeHg), which bioaccumulates. This results in potentially toxic body burdens in high trophic level organisms in aquatic ecosystems and maternal transfer to offspring. We previously demonstrated effects on developing fish including hyperactivity, altered time-to-hatch, reduced survival, and dysregulation of the dopaminergic system. A link between gut microbiota and central nervous system function in teleosts has been established with implications for behavior. We sequenced gut microbiomes of fathead minnows exposed to dietary MeHg to determine microbiome effects. Dietary exposures were repeated with adult CD-1 mice. Metabolomics was used to screen for metabolome changes in mouse brain and larval fish, and results indicate effects on lipid metabolism and neurotransmission, supported by microbiome data. Findings suggest environmentally relevant exposure scenarios may cause xenobiotic-mediated dysbiosis of the gut microbiome, contributing to neurotoxicity. Furthermore, small-bodied teleosts may be a useful model species for studying certain types of neurodegenerative diseases, in lieu of higher vertebrates.

Original languageEnglish
Pages (from-to)8774-8784
Number of pages11
JournalEnvironmental Science and Technology
Volume52
Issue number15
DOIs
StatePublished - 7 Aug 2018

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methylmercury
Fish
Neurodegenerative diseases
teleost
Hatches
Aquatic ecosystems
Poisons
Neurology
Xenobiotics
Mercury
Brain
xenobiotics
Impurities
nervous system
fish
aquatic ecosystem
trophic level
brain
vertebrate
metabolism

Cite this

Bridges, Kristin N. ; Zhang, Yan ; Curran, Thomas E. ; Magnuson, Jason T. ; Venables, Barney J. ; Durrer, Katherine E. ; Allen, Michael Shane ; Roberts, Aaron P. / Alterations to the Intestinal Microbiome and Metabolome of Pimephales promelas and Mus musculus Following Exposure to Dietary Methylmercury. In: Environmental Science and Technology. 2018 ; Vol. 52, No. 15. pp. 8774-8784.
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abstract = "Mercury is a global contaminant, which may be microbially transformed into methylmercury (MeHg), which bioaccumulates. This results in potentially toxic body burdens in high trophic level organisms in aquatic ecosystems and maternal transfer to offspring. We previously demonstrated effects on developing fish including hyperactivity, altered time-to-hatch, reduced survival, and dysregulation of the dopaminergic system. A link between gut microbiota and central nervous system function in teleosts has been established with implications for behavior. We sequenced gut microbiomes of fathead minnows exposed to dietary MeHg to determine microbiome effects. Dietary exposures were repeated with adult CD-1 mice. Metabolomics was used to screen for metabolome changes in mouse brain and larval fish, and results indicate effects on lipid metabolism and neurotransmission, supported by microbiome data. Findings suggest environmentally relevant exposure scenarios may cause xenobiotic-mediated dysbiosis of the gut microbiome, contributing to neurotoxicity. Furthermore, small-bodied teleosts may be a useful model species for studying certain types of neurodegenerative diseases, in lieu of higher vertebrates.",
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Alterations to the Intestinal Microbiome and Metabolome of Pimephales promelas and Mus musculus Following Exposure to Dietary Methylmercury. / Bridges, Kristin N.; Zhang, Yan; Curran, Thomas E.; Magnuson, Jason T.; Venables, Barney J.; Durrer, Katherine E.; Allen, Michael Shane; Roberts, Aaron P.

In: Environmental Science and Technology, Vol. 52, No. 15, 07.08.2018, p. 8774-8784.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Magnuson, Jason T.

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AU - Allen, Michael Shane

AU - Roberts, Aaron P.

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