Alterations in the time of X chromosome replication induced by 5-azacytidine in a patient with 48,XXXY/47,XXY

P. Gregory, C. Greene, E. Shapira, N. Wang

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

It has recently been shown that 5-azacylidine (5-azaC) can induce altered replication patterns of the late-replicating X chromosome in normal female cells. This has been demonstrated by bromodeoxyuridine labelling of cells late in the S phase. In the present study the same method was applied to the lymphocytes of a Klinefelter patient (48,XXXY/47,XXY). Significant 5-azaC-induced changes in the replication of the entire inactive X chromosome, from late to early, were found in the lymphocytes of this palient. These results indicate that hypomethylating agents can not only alter the replication of individual bands, but also change the gross replication schedule of multiple inactive X chromosomes in the presence of a Y chromosome.

Original languageEnglish
Pages (from-to)234-236
Number of pages3
JournalCytogenetic and Genome Research
Volume39
Issue number3
DOIs
StatePublished - 1985

Fingerprint Dive into the research topics of 'Alterations in the time of X chromosome replication induced by 5-azacytidine in a patient with 48,XXXY/47,XXY'. Together they form a unique fingerprint.

Cite this