Abstract
1.Amphotericin B (AmB) increased unidirectional Na transport and net transcellular sodium movements across the skin of the frog, Rana pipiens, when added to the solution bathing the corium side, but not from the outer epidermal surface. 2. The AmB response was prevented with pretreatment with amiloride, ouabain and mueosal sodium substitution. 3. Alteration in pH markedly reduced the permeability changes induced by AmB. 4. AmB did not interfere with the increase in sodium transport induced by antidiuretic hormone. 5. The present study demonstrates that AmB interacts with the skin of the frog, Rana pipiens, from the corium side specifically increasing transepithelial sodium transport. The increase in transport apparently occurs through the existing sodium pathway.
| Original language | English |
|---|---|
| Pages (from-to) | 109-114 |
| Number of pages | 6 |
| Journal | Comparative Biochemistry and Physiology. Part C, Comparative |
| Volume | 80 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1 Jan 1985 |
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Alteration of membrane permeability by amphotericin B. / Benoit, P. A.; Yorio, Thomas.
In: Comparative Biochemistry and Physiology. Part C, Comparative, Vol. 80, No. 1, 01.01.1985, p. 109-114.Research output: Contribution to journal › Article
TY - JOUR
T1 - Alteration of membrane permeability by amphotericin B
AU - Benoit, P. A.
AU - Yorio, Thomas
PY - 1985/1/1
Y1 - 1985/1/1
N2 - 1.Amphotericin B (AmB) increased unidirectional Na transport and net transcellular sodium movements across the skin of the frog, Rana pipiens, when added to the solution bathing the corium side, but not from the outer epidermal surface. 2. The AmB response was prevented with pretreatment with amiloride, ouabain and mueosal sodium substitution. 3. Alteration in pH markedly reduced the permeability changes induced by AmB. 4. AmB did not interfere with the increase in sodium transport induced by antidiuretic hormone. 5. The present study demonstrates that AmB interacts with the skin of the frog, Rana pipiens, from the corium side specifically increasing transepithelial sodium transport. The increase in transport apparently occurs through the existing sodium pathway.
AB - 1.Amphotericin B (AmB) increased unidirectional Na transport and net transcellular sodium movements across the skin of the frog, Rana pipiens, when added to the solution bathing the corium side, but not from the outer epidermal surface. 2. The AmB response was prevented with pretreatment with amiloride, ouabain and mueosal sodium substitution. 3. Alteration in pH markedly reduced the permeability changes induced by AmB. 4. AmB did not interfere with the increase in sodium transport induced by antidiuretic hormone. 5. The present study demonstrates that AmB interacts with the skin of the frog, Rana pipiens, from the corium side specifically increasing transepithelial sodium transport. The increase in transport apparently occurs through the existing sodium pathway.
UR - http://www.scopus.com/inward/record.url?scp=0021958683&partnerID=8YFLogxK
U2 - 10.1016/0742-8413(85)90140-9
DO - 10.1016/0742-8413(85)90140-9
M3 - Article
C2 - 2858329
AN - SCOPUS:0021958683
VL - 80
SP - 109
EP - 114
JO - Comparative Biochemistry and Physiology. Part C, Comparative
JF - Comparative Biochemistry and Physiology. Part C, Comparative
SN - 0306-4492
IS - 1
ER -