Alteration of membrane permeability by amphotericin B

P. A. Benoit, T. Yorio

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

1.Amphotericin B (AmB) increased unidirectional Na transport and net transcellular sodium movements across the skin of the frog, Rana pipiens, when added to the solution bathing the corium side, but not from the outer epidermal surface. 2. The AmB response was prevented with pretreatment with amiloride, ouabain and mueosal sodium substitution. 3. Alteration in pH markedly reduced the permeability changes induced by AmB. 4. AmB did not interfere with the increase in sodium transport induced by antidiuretic hormone. 5. The present study demonstrates that AmB interacts with the skin of the frog, Rana pipiens, from the corium side specifically increasing transepithelial sodium transport. The increase in transport apparently occurs through the existing sodium pathway.

Original languageEnglish
Pages (from-to)109-114
Number of pages6
JournalComparative Biochemistry and Physiology. Part C, Comparative
Volume80
Issue number1
DOIs
StatePublished - 1985

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