Alteration in membrane permeability by diacylglycerol and phosphatidylcholine containing arachidonic acid

Thomas Yorio, Susana Torres, Nimnan Tarapoom

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The phospholipid metabolites, stearoylarachidonylglycerol and diarachidonylglycerol, stimulate transepithelial sodium transport in frog skin epithelium. The increase in Na transport is due to an increase in the unidirectional influx of sodium, is amiloride sensitive and is prevented with pretreatment with indomethacin, mefanamic acid and phospholipase inhibitor, mepacrine. The data suggest a possible role of phospholipid metabolism and prostaglandin biosynthesis in the regulation of transepithelial ion transport.

Original languageEnglish
Pages (from-to)96-99
Number of pages4
JournalLipids
Volume18
Issue number1
DOIs
StatePublished - 1 Jan 1983

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