Alteration in membrane permeability by diacylglycerol and phosphatidylcholine containing arachidonic acid

Thomas Yorio; Susana Torres; Nimnan Tarapoom

doi:10.1007/BF02534698

Alteration in membrane permeability by diacylglycerol and phosphatidylcholine containing arachidonic acid

Thomas Yorio, Susana Torres, Nimnan Tarapoom

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Abstract

The phospholipid metabolites, stearoylarachidonylglycerol and diarachidonylglycerol, stimulate transepithelial sodium transport in frog skin epithelium. The increase in Na transport is due to an increase in the unidirectional influx of sodium, is amiloride sensitive and is prevented with pretreatment with indomethacin, mefanamic acid and phospholipase inhibitor, mepacrine. The data suggest a possible role of phospholipid metabolism and prostaglandin biosynthesis in the regulation of transepithelial ion transport.

Original language	English
Pages (from-to)	96-99
Number of pages	4
Journal	Lipids
Volume	18
Issue number	1
DOIs	https://doi.org/10.1007/BF02534698
State	Published - 1 Jan 1983

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title = "Alteration in membrane permeability by diacylglycerol and phosphatidylcholine containing arachidonic acid",

abstract = "The phospholipid metabolites, stearoylarachidonylglycerol and diarachidonylglycerol, stimulate transepithelial sodium transport in frog skin epithelium. The increase in Na transport is due to an increase in the unidirectional influx of sodium, is amiloride sensitive and is prevented with pretreatment with indomethacin, mefanamic acid and phospholipase inhibitor, mepacrine. The data suggest a possible role of phospholipid metabolism and prostaglandin biosynthesis in the regulation of transepithelial ion transport.",

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N2 - The phospholipid metabolites, stearoylarachidonylglycerol and diarachidonylglycerol, stimulate transepithelial sodium transport in frog skin epithelium. The increase in Na transport is due to an increase in the unidirectional influx of sodium, is amiloride sensitive and is prevented with pretreatment with indomethacin, mefanamic acid and phospholipase inhibitor, mepacrine. The data suggest a possible role of phospholipid metabolism and prostaglandin biosynthesis in the regulation of transepithelial ion transport.

AB - The phospholipid metabolites, stearoylarachidonylglycerol and diarachidonylglycerol, stimulate transepithelial sodium transport in frog skin epithelium. The increase in Na transport is due to an increase in the unidirectional influx of sodium, is amiloride sensitive and is prevented with pretreatment with indomethacin, mefanamic acid and phospholipase inhibitor, mepacrine. The data suggest a possible role of phospholipid metabolism and prostaglandin biosynthesis in the regulation of transepithelial ion transport.

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Alteration in membrane permeability by diacylglycerol and phosphatidylcholine containing arachidonic acid

Abstract

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