Allopatric tuberculosis host-pathogen relationships are associated with greater pulmonary impairment

Jotam G. Pasipanodya, Patrick K. Moonan, Edgar Vecino, Thaddeus L. Miller, Michel Fernandez, Philip Slocum, Gerry Drewyer, Stephen Weis

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Abstract

Background: Host pathogen relationships can be classified as allopatric, when the pathogens originated from separate, non-overlapping geographic areas from the host; or sympatric, when host and pathogen shared a common ancestral geographic location. It remains unclear if host-pathogen relationships, as defined by phylogenetic lineage, influence clinical outcome. We sought to examine the association between allopatric and sympatric phylogenetic Mycobacterium tuberculosis lineages and pulmonary impairment after tuberculosis (PIAT). Methods: Pulmonary function tests were performed on patients 16. years of age and older who had received ≥20. weeks of treatment for culture-confirmed M. tuberculosis complex. Forced Expiratory Volume in 1. min (FEV1) ≥80%, Forced Vital Capacity (FVC) ≥80% and FEV1/FVC >70% of predicted were considered normal. Other results defined pulmonary impairment. Spoligotype and 12-locus mycobacterial interspersed repetitive units-variable number of tandem repeats (MIRU-VNTR) were used to assign phylogenetic lineage. PIAT severity was compared between host-pathogen relationships which were defined by geography and ethnic population. We used multivariate logistic regression modeling to calculate adjusted odds ratios (aOR) to assess the association between phylogenetic lineage and PIAT. Results: Self-reported continental ancestry was correlated with Mycobacterium. tuberculosis lineage (p<. 0.001). In multivariate analyses adjusting for phylogenetic lineage, age and smoking, the overall aOR for subjects with allopatric host-pathogen relationships and PIAT was 1.8 (95% confidence interval [CI]: 1.1, 2.9) compared to sympatric relationships. Smoking >30. pack-years was also associated with PIAT (aOR: 3.2; 95% CI: 1.5, 7.2) relative to smoking <1. pack-years. Conclusions: PIAT frequency and severity varies by host-pathogen relationship and heavy cigarette consumption, but not phylogenetic lineage alone. Patients who had disease resulting from allopatric-host-pathogen relationship were more likely to have PIAT than patients with disease from sympatric-host-pathogen relationship infection. Further study of this association may identify ways that treatment and preventive efforts can be tailored to specific lineages and racial/ethnic populations.

Original languageEnglish
Pages (from-to)433-440
Number of pages8
JournalInfection, Genetics and Evolution
Volume16
DOIs
StatePublished - 1 Jun 2013

Fingerprint

tuberculosis
host-pathogen relationships
Tuberculosis
pathogen
lungs
Lung
phylogeny
phylogenetics
Vital Capacity
Mycobacterium tuberculosis
odds ratio
Odds Ratio
Mycobacterium tuberculosis complex
Geographic Locations
Minisatellite Repeats
Geography
cigarettes
minisatellite repeats
pathogens
lung function

Keywords

  • Genotypes
  • Lineage
  • Pulmonary impairment
  • Race/ethnicity
  • Tuberculosis

Cite this

Pasipanodya, Jotam G. ; Moonan, Patrick K. ; Vecino, Edgar ; Miller, Thaddeus L. ; Fernandez, Michel ; Slocum, Philip ; Drewyer, Gerry ; Weis, Stephen. / Allopatric tuberculosis host-pathogen relationships are associated with greater pulmonary impairment. In: Infection, Genetics and Evolution. 2013 ; Vol. 16. pp. 433-440.
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title = "Allopatric tuberculosis host-pathogen relationships are associated with greater pulmonary impairment",
abstract = "Background: Host pathogen relationships can be classified as allopatric, when the pathogens originated from separate, non-overlapping geographic areas from the host; or sympatric, when host and pathogen shared a common ancestral geographic location. It remains unclear if host-pathogen relationships, as defined by phylogenetic lineage, influence clinical outcome. We sought to examine the association between allopatric and sympatric phylogenetic Mycobacterium tuberculosis lineages and pulmonary impairment after tuberculosis (PIAT). Methods: Pulmonary function tests were performed on patients 16. years of age and older who had received ≥20. weeks of treatment for culture-confirmed M. tuberculosis complex. Forced Expiratory Volume in 1. min (FEV1) ≥80{\%}, Forced Vital Capacity (FVC) ≥80{\%} and FEV1/FVC >70{\%} of predicted were considered normal. Other results defined pulmonary impairment. Spoligotype and 12-locus mycobacterial interspersed repetitive units-variable number of tandem repeats (MIRU-VNTR) were used to assign phylogenetic lineage. PIAT severity was compared between host-pathogen relationships which were defined by geography and ethnic population. We used multivariate logistic regression modeling to calculate adjusted odds ratios (aOR) to assess the association between phylogenetic lineage and PIAT. Results: Self-reported continental ancestry was correlated with Mycobacterium. tuberculosis lineage (p<. 0.001). In multivariate analyses adjusting for phylogenetic lineage, age and smoking, the overall aOR for subjects with allopatric host-pathogen relationships and PIAT was 1.8 (95{\%} confidence interval [CI]: 1.1, 2.9) compared to sympatric relationships. Smoking >30. pack-years was also associated with PIAT (aOR: 3.2; 95{\%} CI: 1.5, 7.2) relative to smoking <1. pack-years. Conclusions: PIAT frequency and severity varies by host-pathogen relationship and heavy cigarette consumption, but not phylogenetic lineage alone. Patients who had disease resulting from allopatric-host-pathogen relationship were more likely to have PIAT than patients with disease from sympatric-host-pathogen relationship infection. Further study of this association may identify ways that treatment and preventive efforts can be tailored to specific lineages and racial/ethnic populations.",
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Allopatric tuberculosis host-pathogen relationships are associated with greater pulmonary impairment. / Pasipanodya, Jotam G.; Moonan, Patrick K.; Vecino, Edgar; Miller, Thaddeus L.; Fernandez, Michel; Slocum, Philip; Drewyer, Gerry; Weis, Stephen.

In: Infection, Genetics and Evolution, Vol. 16, 01.06.2013, p. 433-440.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Allopatric tuberculosis host-pathogen relationships are associated with greater pulmonary impairment

AU - Pasipanodya, Jotam G.

AU - Moonan, Patrick K.

AU - Vecino, Edgar

AU - Miller, Thaddeus L.

AU - Fernandez, Michel

AU - Slocum, Philip

AU - Drewyer, Gerry

AU - Weis, Stephen

PY - 2013/6/1

Y1 - 2013/6/1

N2 - Background: Host pathogen relationships can be classified as allopatric, when the pathogens originated from separate, non-overlapping geographic areas from the host; or sympatric, when host and pathogen shared a common ancestral geographic location. It remains unclear if host-pathogen relationships, as defined by phylogenetic lineage, influence clinical outcome. We sought to examine the association between allopatric and sympatric phylogenetic Mycobacterium tuberculosis lineages and pulmonary impairment after tuberculosis (PIAT). Methods: Pulmonary function tests were performed on patients 16. years of age and older who had received ≥20. weeks of treatment for culture-confirmed M. tuberculosis complex. Forced Expiratory Volume in 1. min (FEV1) ≥80%, Forced Vital Capacity (FVC) ≥80% and FEV1/FVC >70% of predicted were considered normal. Other results defined pulmonary impairment. Spoligotype and 12-locus mycobacterial interspersed repetitive units-variable number of tandem repeats (MIRU-VNTR) were used to assign phylogenetic lineage. PIAT severity was compared between host-pathogen relationships which were defined by geography and ethnic population. We used multivariate logistic regression modeling to calculate adjusted odds ratios (aOR) to assess the association between phylogenetic lineage and PIAT. Results: Self-reported continental ancestry was correlated with Mycobacterium. tuberculosis lineage (p<. 0.001). In multivariate analyses adjusting for phylogenetic lineage, age and smoking, the overall aOR for subjects with allopatric host-pathogen relationships and PIAT was 1.8 (95% confidence interval [CI]: 1.1, 2.9) compared to sympatric relationships. Smoking >30. pack-years was also associated with PIAT (aOR: 3.2; 95% CI: 1.5, 7.2) relative to smoking <1. pack-years. Conclusions: PIAT frequency and severity varies by host-pathogen relationship and heavy cigarette consumption, but not phylogenetic lineage alone. Patients who had disease resulting from allopatric-host-pathogen relationship were more likely to have PIAT than patients with disease from sympatric-host-pathogen relationship infection. Further study of this association may identify ways that treatment and preventive efforts can be tailored to specific lineages and racial/ethnic populations.

AB - Background: Host pathogen relationships can be classified as allopatric, when the pathogens originated from separate, non-overlapping geographic areas from the host; or sympatric, when host and pathogen shared a common ancestral geographic location. It remains unclear if host-pathogen relationships, as defined by phylogenetic lineage, influence clinical outcome. We sought to examine the association between allopatric and sympatric phylogenetic Mycobacterium tuberculosis lineages and pulmonary impairment after tuberculosis (PIAT). Methods: Pulmonary function tests were performed on patients 16. years of age and older who had received ≥20. weeks of treatment for culture-confirmed M. tuberculosis complex. Forced Expiratory Volume in 1. min (FEV1) ≥80%, Forced Vital Capacity (FVC) ≥80% and FEV1/FVC >70% of predicted were considered normal. Other results defined pulmonary impairment. Spoligotype and 12-locus mycobacterial interspersed repetitive units-variable number of tandem repeats (MIRU-VNTR) were used to assign phylogenetic lineage. PIAT severity was compared between host-pathogen relationships which were defined by geography and ethnic population. We used multivariate logistic regression modeling to calculate adjusted odds ratios (aOR) to assess the association between phylogenetic lineage and PIAT. Results: Self-reported continental ancestry was correlated with Mycobacterium. tuberculosis lineage (p<. 0.001). In multivariate analyses adjusting for phylogenetic lineage, age and smoking, the overall aOR for subjects with allopatric host-pathogen relationships and PIAT was 1.8 (95% confidence interval [CI]: 1.1, 2.9) compared to sympatric relationships. Smoking >30. pack-years was also associated with PIAT (aOR: 3.2; 95% CI: 1.5, 7.2) relative to smoking <1. pack-years. Conclusions: PIAT frequency and severity varies by host-pathogen relationship and heavy cigarette consumption, but not phylogenetic lineage alone. Patients who had disease resulting from allopatric-host-pathogen relationship were more likely to have PIAT than patients with disease from sympatric-host-pathogen relationship infection. Further study of this association may identify ways that treatment and preventive efforts can be tailored to specific lineages and racial/ethnic populations.

KW - Genotypes

KW - Lineage

KW - Pulmonary impairment

KW - Race/ethnicity

KW - Tuberculosis

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