Age-related impairment of vascular structure and functions

Xianglai Xu, Brian Wang, Changhong Ren, Jiangnan Hu, David A. Greenberg, Tianxiang Chen, Liping Xie, Kunlin Jin

Research output: Contribution to journalReview articlepeer-review

57 Scopus citations


Among age-related diseases, cardiovascular and cerebrovascular diseases are major causes of death. Vascular dysfunction is a key characteristic of these diseases wherein age is an independent and essential risk factor. The present work will review morphological alterations of aging vessels in-depth, which includes the discussion of age-related microvessel loss and changes to vasculature involving the capillary basement membrane, intima, media, and adventitia as well as the accompanying vascular dysfunctions arising from these alterations.

Original languageEnglish
Pages (from-to)590-610
Number of pages21
JournalAging and Disease
Issue number5
StatePublished - 1 Oct 2017


  • Arterial stiffness
  • Endothelial dysfunction
  • Vascular aging
  • Vascular remodeling

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