The hematological changes resulting from individual and combined administration of ethanol and diazepam were studied in young and old rats. Ethanol and, ethanol and diazepam treated rats of both age groups showed a decrease in the counts of red blood cells (RBC), white blood cells (WBC), hemoglobin content (Hb) and packed cell volume (PCV), whereas the specific activities of serum glutamate oxaloacetate transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT) were significantly increased. Though diazepam also produced similar changes in old rats, no significant changes were observed in young rats. The alterations observed in the study were augmented during senescence and also following combined administration of ethanol and diazepam. These results suggest that during aging, a high degree of alterations are manifested in the hemopoetic system as a consequence of potentiating effects of diazepam and ethanol.
|Number of pages||4|
|Journal||Research Communications in Alcohol and Substances of Abuse|
|State||Published - 1 Dec 2001|