TY - JOUR
T1 - Age differences in acquisition and retention of one-way avoidance learning in C57BL/6NNia and autoimmune mice
AU - Forster, Michael J.
AU - Popper, Mark D.
AU - Retz, Konrad C.
AU - Lal, Harbans
N1 - Funding Information:
J Supported by NIH grants AG06182 (M.J.F.), RR05879, and a research grant from Bristol-Myers Company (K.C.R.). We are grateful to Drs. Subir K. Paul and Bala Kumar, and to Michael D. O'Verly and Nancy Frantz for their assistance in the experimental work. Correspondence should be addressed to Michael J. Forster, Ph.D., Department of Pharmacology, Texas College of Osteopathic Medicine, 3516 Camp Bowie Boulevard, Fort Worth, TX 76107-2690.
PY - 1988/3
Y1 - 1988/3
N2 - Acquisition and 48-h retention of a step-up active avoidance response were studied in separate age groups of C57BL/6NNia mice (aged 1.5, 3.5, 6, 12, or 26 months) and five strains of genetically autoimmune mice differing in life span. The C57BL/6NNia mice showed no change in ability to acquire the avoidance response between 1.5 and 3.5 months, but showed a steady decline in that ability thereafter. Mouse strains with early-onset autoimmune disorder (NZB/B1NJ, MRL/MpJ-lpr, and BXSB/MpJ) showed declines in acquisition capability between 1.5 and 3.5 months of age, whereas mouse strains with mild, late-onset autoimmune disorder (MRL/MpJ - + and NZBWF1/J) showed stable or improved acquisition during that period. Both the C57BL/6NNia and NZB/BINJ mice showed age-dependent declines in 48-h retention performance by 12 months of age. These findings suggested that while 48-h retention performance deficits were most related to chronological age, avoidance acquisition deficits were related to development of autoimmunity.
AB - Acquisition and 48-h retention of a step-up active avoidance response were studied in separate age groups of C57BL/6NNia mice (aged 1.5, 3.5, 6, 12, or 26 months) and five strains of genetically autoimmune mice differing in life span. The C57BL/6NNia mice showed no change in ability to acquire the avoidance response between 1.5 and 3.5 months, but showed a steady decline in that ability thereafter. Mouse strains with early-onset autoimmune disorder (NZB/B1NJ, MRL/MpJ-lpr, and BXSB/MpJ) showed declines in acquisition capability between 1.5 and 3.5 months of age, whereas mouse strains with mild, late-onset autoimmune disorder (MRL/MpJ - + and NZBWF1/J) showed stable or improved acquisition during that period. Both the C57BL/6NNia and NZB/BINJ mice showed age-dependent declines in 48-h retention performance by 12 months of age. These findings suggested that while 48-h retention performance deficits were most related to chronological age, avoidance acquisition deficits were related to development of autoimmunity.
UR - http://www.scopus.com/inward/record.url?scp=0023872189&partnerID=8YFLogxK
U2 - 10.1016/S0163-1047(88)90462-1
DO - 10.1016/S0163-1047(88)90462-1
M3 - Article
C2 - 3365183
AN - SCOPUS:0023872189
SN - 0163-1047
VL - 49
SP - 139
EP - 151
JO - Behavioral and Neural Biology
JF - Behavioral and Neural Biology
IS - 2
ER -