Age-dependent enhancement of diazepam sensitivity is accelerated in New Zealand black mice

Michael J. Forster; Konrad C. Retz; Mark D. Popper; Harbans Lal

doi:10.1016/0024-3205(86)90477-7

Age-dependent enhancement of diazepam sensitivity is accelerated in New Zealand black mice

Michael J. Forster, Konrad C. Retz, Mark D. Popper, Harbans Lal

Institute for Healthy Aging

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20 Scopus citations

Abstract

Separate age groups of C57BL/6 and autoimmune New Zealand Black (NZB) mice were compared for diazepam-induced ataxia and barbiturate-induced loss of righting reflex. Between 1 and 3 months of age, both strains showed a similar age-related decrease in ED50 for diazepam-induced ataxia. However, between 3 and 12 months the decrease in ED50 was markedly greater in NZB mice. In contrast, age-related increases in the durations of loss of righting reflex following hexobarbital or barbital were similar in both strains. The results suggest that NZB mice show relatively accelerated age-related increases in sensitivity to benzodiazepine, but not to barbiturates.

Original language	English
Pages (from-to)	1433-1439
Number of pages	7
Journal	Life Sciences
Volume	38
Issue number	15
DOIs	https://doi.org/10.1016/0024-3205(86)90477-7
Publication status	Published - 14 Apr 1986

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Forster, M. J., Retz, K. C., Popper, M. D., & Lal, H. (1986). Age-dependent enhancement of diazepam sensitivity is accelerated in New Zealand black mice. Life Sciences, 38(15), 1433-1439. https://doi.org/10.1016/0024-3205(86)90477-7

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abstract = "Separate age groups of C57BL/6 and autoimmune New Zealand Black (NZB) mice were compared for diazepam-induced ataxia and barbiturate-induced loss of righting reflex. Between 1 and 3 months of age, both strains showed a similar age-related decrease in ED50 for diazepam-induced ataxia. However, between 3 and 12 months the decrease in ED50 was markedly greater in NZB mice. In contrast, age-related increases in the durations of loss of righting reflex following hexobarbital or barbital were similar in both strains. The results suggest that NZB mice show relatively accelerated age-related increases in sensitivity to benzodiazepine, but not to barbiturates.",

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AU - Forster, Michael J.

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N2 - Separate age groups of C57BL/6 and autoimmune New Zealand Black (NZB) mice were compared for diazepam-induced ataxia and barbiturate-induced loss of righting reflex. Between 1 and 3 months of age, both strains showed a similar age-related decrease in ED50 for diazepam-induced ataxia. However, between 3 and 12 months the decrease in ED50 was markedly greater in NZB mice. In contrast, age-related increases in the durations of loss of righting reflex following hexobarbital or barbital were similar in both strains. The results suggest that NZB mice show relatively accelerated age-related increases in sensitivity to benzodiazepine, but not to barbiturates.

AB - Separate age groups of C57BL/6 and autoimmune New Zealand Black (NZB) mice were compared for diazepam-induced ataxia and barbiturate-induced loss of righting reflex. Between 1 and 3 months of age, both strains showed a similar age-related decrease in ED50 for diazepam-induced ataxia. However, between 3 and 12 months the decrease in ED50 was markedly greater in NZB mice. In contrast, age-related increases in the durations of loss of righting reflex following hexobarbital or barbital were similar in both strains. The results suggest that NZB mice show relatively accelerated age-related increases in sensitivity to benzodiazepine, but not to barbiturates.

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10.1016/0024-3205(86)90477-7

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