Age-dependent enhancement of diazepam sensitivity is accelerated in New Zealand black mice

Michael J. Forster; Konrad C. Retz; Mark D. Popper; Harbans Lal

doi:10.1016/0024-3205(86)90477-7

Age-dependent enhancement of diazepam sensitivity is accelerated in New Zealand black mice

Michael J. Forster, Konrad C. Retz, Mark D. Popper, Harbans Lal

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Abstract

Separate age groups of C57BL/6 and autoimmune New Zealand Black (NZB) mice were compared for diazepam-induced ataxia and barbiturate-induced loss of righting reflex. Between 1 and 3 months of age, both strains showed a similar age-related decrease in ED50 for diazepam-induced ataxia. However, between 3 and 12 months the decrease in ED50 was markedly greater in NZB mice. In contrast, age-related increases in the durations of loss of righting reflex following hexobarbital or barbital were similar in both strains. The results suggest that NZB mice show relatively accelerated age-related increases in sensitivity to benzodiazepine, but not to barbiturates.

Original language	English
Pages (from-to)	1433-1439
Number of pages	7
Journal	Life Sciences
Volume	38
Issue number	15
DOIs	https://doi.org/10.1016/0024-3205(86)90477-7
State	Published - 14 Apr 1986

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title = "Age-dependent enhancement of diazepam sensitivity is accelerated in New Zealand black mice",

abstract = "Separate age groups of C57BL/6 and autoimmune New Zealand Black (NZB) mice were compared for diazepam-induced ataxia and barbiturate-induced loss of righting reflex. Between 1 and 3 months of age, both strains showed a similar age-related decrease in ED50 for diazepam-induced ataxia. However, between 3 and 12 months the decrease in ED50 was markedly greater in NZB mice. In contrast, age-related increases in the durations of loss of righting reflex following hexobarbital or barbital were similar in both strains. The results suggest that NZB mice show relatively accelerated age-related increases in sensitivity to benzodiazepine, but not to barbiturates.",

author = "Forster, {Michael J.} and Retz, {Konrad C.} and Popper, {Mark D.} and Harbans Lal",

note = "Funding Information: This research was partially supported by U.S.P.H.S. grant AG03623. The authors thank Hoffmann-La Roche for their donation of diazepam.",

year = "1986",

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doi = "10.1016/0024-3205(86)90477-7",

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TY - JOUR

T1 - Age-dependent enhancement of diazepam sensitivity is accelerated in New Zealand black mice

AU - Forster, Michael J.

AU - Retz, Konrad C.

AU - Popper, Mark D.

AU - Lal, Harbans

N1 - Funding Information: This research was partially supported by U.S.P.H.S. grant AG03623. The authors thank Hoffmann-La Roche for their donation of diazepam.

PY - 1986/4/14

Y1 - 1986/4/14

N2 - Separate age groups of C57BL/6 and autoimmune New Zealand Black (NZB) mice were compared for diazepam-induced ataxia and barbiturate-induced loss of righting reflex. Between 1 and 3 months of age, both strains showed a similar age-related decrease in ED50 for diazepam-induced ataxia. However, between 3 and 12 months the decrease in ED50 was markedly greater in NZB mice. In contrast, age-related increases in the durations of loss of righting reflex following hexobarbital or barbital were similar in both strains. The results suggest that NZB mice show relatively accelerated age-related increases in sensitivity to benzodiazepine, but not to barbiturates.

AB - Separate age groups of C57BL/6 and autoimmune New Zealand Black (NZB) mice were compared for diazepam-induced ataxia and barbiturate-induced loss of righting reflex. Between 1 and 3 months of age, both strains showed a similar age-related decrease in ED50 for diazepam-induced ataxia. However, between 3 and 12 months the decrease in ED50 was markedly greater in NZB mice. In contrast, age-related increases in the durations of loss of righting reflex following hexobarbital or barbital were similar in both strains. The results suggest that NZB mice show relatively accelerated age-related increases in sensitivity to benzodiazepine, but not to barbiturates.

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DO - 10.1016/0024-3205(86)90477-7

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JO - Life Sciences

JF - Life Sciences

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ER -

Age-dependent enhancement of diazepam sensitivity is accelerated in New Zealand black mice

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