African origin of modern humans in East Asia: A tale of 12,000 Y chromosomes

Yuehai Ke, Bing Su, Xiufeng Song, Daru Lu, Lifeng Chen, Hongyu Li, Chunjian Qi, Sangkot Marzuki, Ranjan Deka, Peter Underhill, Chunjie Xiao, Mark Shriver, Jeff Lell, Douglas Wallace, R. Spencer Wells, Mark Seielstad, Peter Oefner, Dingliang Zhu, Jianzhong Jin, Wei HuangRanajit Chakraborty, Zhu Chen, Li Jin

Research output: Contribution to journalArticle

159 Citations (Scopus)

Abstract

To test the hypotheses of modern human origin in East Asia, we sampled 12,127 male individuals from 163 populations and typed for three Y chromosome biallelic markers (YAP, M89, and M130). All the individuals carried a mutation at one of the three sites. These three mutations (YAP+, M89T, and M130T) coalesce to another mutation (M168T), which originated in Africa about 35,000 to 89,000 years ago. Therefore, the data do not support even a minimal in situ hominid contribution in the origin of anatomically modern humans in East Asia.

Original languageEnglish
Pages (from-to)1151-1153
Number of pages3
JournalScience
Volume292
Issue number5519
DOIs
StatePublished - 11 May 2001

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Far East
Y Chromosome
Mutation
Hominidae
Genetic Markers
Population

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Ke, Y., Su, B., Song, X., Lu, D., Chen, L., Li, H., ... Jin, L. (2001). African origin of modern humans in East Asia: A tale of 12,000 Y chromosomes. Science, 292(5519), 1151-1153. https://doi.org/10.1126/science.1060011
Ke, Yuehai ; Su, Bing ; Song, Xiufeng ; Lu, Daru ; Chen, Lifeng ; Li, Hongyu ; Qi, Chunjian ; Marzuki, Sangkot ; Deka, Ranjan ; Underhill, Peter ; Xiao, Chunjie ; Shriver, Mark ; Lell, Jeff ; Wallace, Douglas ; Wells, R. Spencer ; Seielstad, Mark ; Oefner, Peter ; Zhu, Dingliang ; Jin, Jianzhong ; Huang, Wei ; Chakraborty, Ranajit ; Chen, Zhu ; Jin, Li. / African origin of modern humans in East Asia : A tale of 12,000 Y chromosomes. In: Science. 2001 ; Vol. 292, No. 5519. pp. 1151-1153.
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abstract = "To test the hypotheses of modern human origin in East Asia, we sampled 12,127 male individuals from 163 populations and typed for three Y chromosome biallelic markers (YAP, M89, and M130). All the individuals carried a mutation at one of the three sites. These three mutations (YAP+, M89T, and M130T) coalesce to another mutation (M168T), which originated in Africa about 35,000 to 89,000 years ago. Therefore, the data do not support even a minimal in situ hominid contribution in the origin of anatomically modern humans in East Asia.",
author = "Yuehai Ke and Bing Su and Xiufeng Song and Daru Lu and Lifeng Chen and Hongyu Li and Chunjian Qi and Sangkot Marzuki and Ranjan Deka and Peter Underhill and Chunjie Xiao and Mark Shriver and Jeff Lell and Douglas Wallace and Wells, {R. Spencer} and Mark Seielstad and Peter Oefner and Dingliang Zhu and Jianzhong Jin and Wei Huang and Ranajit Chakraborty and Zhu Chen and Li Jin",
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Ke, Y, Su, B, Song, X, Lu, D, Chen, L, Li, H, Qi, C, Marzuki, S, Deka, R, Underhill, P, Xiao, C, Shriver, M, Lell, J, Wallace, D, Wells, RS, Seielstad, M, Oefner, P, Zhu, D, Jin, J, Huang, W, Chakraborty, R, Chen, Z & Jin, L 2001, 'African origin of modern humans in East Asia: A tale of 12,000 Y chromosomes', Science, vol. 292, no. 5519, pp. 1151-1153. https://doi.org/10.1126/science.1060011

African origin of modern humans in East Asia : A tale of 12,000 Y chromosomes. / Ke, Yuehai; Su, Bing; Song, Xiufeng; Lu, Daru; Chen, Lifeng; Li, Hongyu; Qi, Chunjian; Marzuki, Sangkot; Deka, Ranjan; Underhill, Peter; Xiao, Chunjie; Shriver, Mark; Lell, Jeff; Wallace, Douglas; Wells, R. Spencer; Seielstad, Mark; Oefner, Peter; Zhu, Dingliang; Jin, Jianzhong; Huang, Wei; Chakraborty, Ranajit; Chen, Zhu; Jin, Li.

In: Science, Vol. 292, No. 5519, 11.05.2001, p. 1151-1153.

Research output: Contribution to journalArticle

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AU - Deka, Ranjan

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AU - Shriver, Mark

AU - Lell, Jeff

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AU - Wells, R. Spencer

AU - Seielstad, Mark

AU - Oefner, Peter

AU - Zhu, Dingliang

AU - Jin, Jianzhong

AU - Huang, Wei

AU - Chakraborty, Ranajit

AU - Chen, Zhu

AU - Jin, Li

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Ke Y, Su B, Song X, Lu D, Chen L, Li H et al. African origin of modern humans in East Asia: A tale of 12,000 Y chromosomes. Science. 2001 May 11;292(5519):1151-1153. https://doi.org/10.1126/science.1060011