Aerobic exercise training improves orthostatic tolerance in aging humans

Diqun Xu, Hong Wang, Shande Chen, Sarah Elizabeth Ross, Hao Liu, Albert Yurvati, Peter B. Raven, Xiangrong Shi

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Abstract

Purpose: This study was designed to test the hypothesis that aerobic exercise training of the elderly will increase aerobic fitness without compromising orthostatic tolerance (OT). Methods: Eight healthy sedentary volunteers (67.0 ± 1.7 yr old, four women) participated in 1 yr of endurance exercise training (stationary bicycle and/or treadmill) program at the individuals' 65%-75% of HRpeak. Peak O2 uptake (VO2peak) and HRpeak were determined by a maximal exercise stress test using a bicycle ergometer. Carotid baroreceptor reflex (CBR) control of HR and mean arterial pressure (MAP) were assessed by a neck pressure-neck suction protocol. Each subject's maximal gain (Gmax), or sensitivity, of the CBR function curves were derived from fitting their reflex HR and MAP responses to the corresponding neck pressure-neck suction stimuli using a logistic function curve. The subjects' OT was assessed using lower-body negative pressure (LBNP) graded to -50 mm Hg; the sum of the product of LBNP intensity and time (mm Hg min-1) was calculated as the cumulative stress index. Results: Training increased VO2peak (before vs after: 22.8 ± 0.92 vs 27.9 ± 1.33 mL min-1 kg-1, P < 0.01) and HRpeak (154 ± 4 vs 159 ± 3 bpm, P < 0.02) and decreased resting HR (65 ± 5 vs 59 ± 5 bpm, P < 0.02) and MAP (99 ± 2 vs 87 ± 2 mm Hg, P < 0.05). CBR stimulus-response curves identified a leftward shift with an increase in CBR-HR Gmax (from -0.13 ± 0.02 to -0.27 ± 0.04 bpm mm Hg-1, P = 0.01). Cumulative stress index was increased from 767 ± 68 mm Hg min-1 pretraining to 946 ± 44 mm Hg min-1 posttraining (P < 0.05). Conclusion: Aerobic exercise training improved the aerobic fitness and OT in elderly subjects. An improved OT is likely associated with an enhanced CBR function that has been reset to better maintain cerebral perfusion and cerebral tissue oxygenation during LBNP.

Original languageEnglish
Pages (from-to)728-735
Number of pages8
JournalMedicine and Science in Sports and Exercise
Volume49
Issue number4
DOIs
StatePublished - 1 Jan 2017

Fingerprint

Baroreflex
Lower Body Negative Pressure
Exercise
Neck
Arterial Pressure
Suction
Exercise Test
Pressure
Reflex
Healthy Volunteers
Perfusion

Keywords

  • Carotid arterial baroreflex
  • Cerebral tissue oxygenation
  • Lower-body negative pressure
  • Peak o uptake
  • Presyncope

Cite this

@article{95fef826c11e46838529a6b60645d2b2,
title = "Aerobic exercise training improves orthostatic tolerance in aging humans",
abstract = "Purpose: This study was designed to test the hypothesis that aerobic exercise training of the elderly will increase aerobic fitness without compromising orthostatic tolerance (OT). Methods: Eight healthy sedentary volunteers (67.0 ± 1.7 yr old, four women) participated in 1 yr of endurance exercise training (stationary bicycle and/or treadmill) program at the individuals' 65{\%}-75{\%} of HRpeak. Peak O2 uptake (VO2peak) and HRpeak were determined by a maximal exercise stress test using a bicycle ergometer. Carotid baroreceptor reflex (CBR) control of HR and mean arterial pressure (MAP) were assessed by a neck pressure-neck suction protocol. Each subject's maximal gain (Gmax), or sensitivity, of the CBR function curves were derived from fitting their reflex HR and MAP responses to the corresponding neck pressure-neck suction stimuli using a logistic function curve. The subjects' OT was assessed using lower-body negative pressure (LBNP) graded to -50 mm Hg; the sum of the product of LBNP intensity and time (mm Hg min-1) was calculated as the cumulative stress index. Results: Training increased VO2peak (before vs after: 22.8 ± 0.92 vs 27.9 ± 1.33 mL min-1 kg-1, P < 0.01) and HRpeak (154 ± 4 vs 159 ± 3 bpm, P < 0.02) and decreased resting HR (65 ± 5 vs 59 ± 5 bpm, P < 0.02) and MAP (99 ± 2 vs 87 ± 2 mm Hg, P < 0.05). CBR stimulus-response curves identified a leftward shift with an increase in CBR-HR Gmax (from -0.13 ± 0.02 to -0.27 ± 0.04 bpm mm Hg-1, P = 0.01). Cumulative stress index was increased from 767 ± 68 mm Hg min-1 pretraining to 946 ± 44 mm Hg min-1 posttraining (P < 0.05). Conclusion: Aerobic exercise training improved the aerobic fitness and OT in elderly subjects. An improved OT is likely associated with an enhanced CBR function that has been reset to better maintain cerebral perfusion and cerebral tissue oxygenation during LBNP.",
keywords = "Carotid arterial baroreflex, Cerebral tissue oxygenation, Lower-body negative pressure, Peak o uptake, Presyncope",
author = "Diqun Xu and Hong Wang and Shande Chen and Ross, {Sarah Elizabeth} and Hao Liu and Albert Yurvati and Raven, {Peter B.} and Xiangrong Shi",
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Aerobic exercise training improves orthostatic tolerance in aging humans. / Xu, Diqun; Wang, Hong; Chen, Shande; Ross, Sarah Elizabeth; Liu, Hao; Yurvati, Albert; Raven, Peter B.; Shi, Xiangrong.

In: Medicine and Science in Sports and Exercise, Vol. 49, No. 4, 01.01.2017, p. 728-735.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Aerobic exercise training improves orthostatic tolerance in aging humans

AU - Xu, Diqun

AU - Wang, Hong

AU - Chen, Shande

AU - Ross, Sarah Elizabeth

AU - Liu, Hao

AU - Yurvati, Albert

AU - Raven, Peter B.

AU - Shi, Xiangrong

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Purpose: This study was designed to test the hypothesis that aerobic exercise training of the elderly will increase aerobic fitness without compromising orthostatic tolerance (OT). Methods: Eight healthy sedentary volunteers (67.0 ± 1.7 yr old, four women) participated in 1 yr of endurance exercise training (stationary bicycle and/or treadmill) program at the individuals' 65%-75% of HRpeak. Peak O2 uptake (VO2peak) and HRpeak were determined by a maximal exercise stress test using a bicycle ergometer. Carotid baroreceptor reflex (CBR) control of HR and mean arterial pressure (MAP) were assessed by a neck pressure-neck suction protocol. Each subject's maximal gain (Gmax), or sensitivity, of the CBR function curves were derived from fitting their reflex HR and MAP responses to the corresponding neck pressure-neck suction stimuli using a logistic function curve. The subjects' OT was assessed using lower-body negative pressure (LBNP) graded to -50 mm Hg; the sum of the product of LBNP intensity and time (mm Hg min-1) was calculated as the cumulative stress index. Results: Training increased VO2peak (before vs after: 22.8 ± 0.92 vs 27.9 ± 1.33 mL min-1 kg-1, P < 0.01) and HRpeak (154 ± 4 vs 159 ± 3 bpm, P < 0.02) and decreased resting HR (65 ± 5 vs 59 ± 5 bpm, P < 0.02) and MAP (99 ± 2 vs 87 ± 2 mm Hg, P < 0.05). CBR stimulus-response curves identified a leftward shift with an increase in CBR-HR Gmax (from -0.13 ± 0.02 to -0.27 ± 0.04 bpm mm Hg-1, P = 0.01). Cumulative stress index was increased from 767 ± 68 mm Hg min-1 pretraining to 946 ± 44 mm Hg min-1 posttraining (P < 0.05). Conclusion: Aerobic exercise training improved the aerobic fitness and OT in elderly subjects. An improved OT is likely associated with an enhanced CBR function that has been reset to better maintain cerebral perfusion and cerebral tissue oxygenation during LBNP.

AB - Purpose: This study was designed to test the hypothesis that aerobic exercise training of the elderly will increase aerobic fitness without compromising orthostatic tolerance (OT). Methods: Eight healthy sedentary volunteers (67.0 ± 1.7 yr old, four women) participated in 1 yr of endurance exercise training (stationary bicycle and/or treadmill) program at the individuals' 65%-75% of HRpeak. Peak O2 uptake (VO2peak) and HRpeak were determined by a maximal exercise stress test using a bicycle ergometer. Carotid baroreceptor reflex (CBR) control of HR and mean arterial pressure (MAP) were assessed by a neck pressure-neck suction protocol. Each subject's maximal gain (Gmax), or sensitivity, of the CBR function curves were derived from fitting their reflex HR and MAP responses to the corresponding neck pressure-neck suction stimuli using a logistic function curve. The subjects' OT was assessed using lower-body negative pressure (LBNP) graded to -50 mm Hg; the sum of the product of LBNP intensity and time (mm Hg min-1) was calculated as the cumulative stress index. Results: Training increased VO2peak (before vs after: 22.8 ± 0.92 vs 27.9 ± 1.33 mL min-1 kg-1, P < 0.01) and HRpeak (154 ± 4 vs 159 ± 3 bpm, P < 0.02) and decreased resting HR (65 ± 5 vs 59 ± 5 bpm, P < 0.02) and MAP (99 ± 2 vs 87 ± 2 mm Hg, P < 0.05). CBR stimulus-response curves identified a leftward shift with an increase in CBR-HR Gmax (from -0.13 ± 0.02 to -0.27 ± 0.04 bpm mm Hg-1, P = 0.01). Cumulative stress index was increased from 767 ± 68 mm Hg min-1 pretraining to 946 ± 44 mm Hg min-1 posttraining (P < 0.05). Conclusion: Aerobic exercise training improved the aerobic fitness and OT in elderly subjects. An improved OT is likely associated with an enhanced CBR function that has been reset to better maintain cerebral perfusion and cerebral tissue oxygenation during LBNP.

KW - Carotid arterial baroreflex

KW - Cerebral tissue oxygenation

KW - Lower-body negative pressure

KW - Peak o uptake

KW - Presyncope

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SN - 0195-9131

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