Advances in research of gene-environment interactions in breast cancer

Jun Yi Jiang; Yong Bing Xiang; Meng Hua Tao; Wang Hong Xu

doi:10.3781/j.issn.1000-7431.2011.06.017

Advances in research of gene-environment interactions in breast cancer

Jun Yi Jiang, Yong Bing Xiang, Meng Hua Tao, Wang Hong Xu

Research output: Contribution to journal › Review article › peer-review

Abstract

Breast cancer is one of the most frequently diagnosed cancers in women. It has been increasingly recognized that breast cancer is a result of interplays between different exposures and host susceptibilities. The study of gene-environment interactions (GEI) has been confined to candidate gene approach which is mainly involving genes related to metabolism, DNA repair, cell apoptosis, etc. Recent genome-wide association studies are identifying novel susceptibility genes of breast cancer. These studies, without any biological hypothesis, provide us not only a promising prospect but also a big challenge in the GEI analysis. This review is aimed to present a summary of recent advances in the understanding of the contribution of the GEI to breast cancer, and thus implicate further research in the area.

Original language	English
Pages (from-to)	558-564
Number of pages	7
Journal	Tumor
Volume	31
Issue number	6
DOIs	https://doi.org/10.3781/j.issn.1000-7431.2011.06.017
State	Published - 1 Jun 2011

Keywords

Breast neoplasms
Gene-environment interaction
Risk factors

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10.3781/j.issn.1000-7431.2011.06.017

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abstract = "Breast cancer is one of the most frequently diagnosed cancers in women. It has been increasingly recognized that breast cancer is a result of interplays between different exposures and host susceptibilities. The study of gene-environment interactions (GEI) has been confined to candidate gene approach which is mainly involving genes related to metabolism, DNA repair, cell apoptosis, etc. Recent genome-wide association studies are identifying novel susceptibility genes of breast cancer. These studies, without any biological hypothesis, provide us not only a promising prospect but also a big challenge in the GEI analysis. This review is aimed to present a summary of recent advances in the understanding of the contribution of the GEI to breast cancer, and thus implicate further research in the area.",

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AB - Breast cancer is one of the most frequently diagnosed cancers in women. It has been increasingly recognized that breast cancer is a result of interplays between different exposures and host susceptibilities. The study of gene-environment interactions (GEI) has been confined to candidate gene approach which is mainly involving genes related to metabolism, DNA repair, cell apoptosis, etc. Recent genome-wide association studies are identifying novel susceptibility genes of breast cancer. These studies, without any biological hypothesis, provide us not only a promising prospect but also a big challenge in the GEI analysis. This review is aimed to present a summary of recent advances in the understanding of the contribution of the GEI to breast cancer, and thus implicate further research in the area.

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Advances in research of gene-environment interactions in breast cancer

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