Advances in research of gene-environment interactions in breast cancer

Jun Yi Jiang, Yong Bing Xiang, Meng Hua Tao, Wang Hong Xu

Research output: Contribution to journalReview article

Abstract

Breast cancer is one of the most frequently diagnosed cancers in women. It has been increasingly recognized that breast cancer is a result of interplays between different exposures and host susceptibilities. The study of gene-environment interactions (GEI) has been confined to candidate gene approach which is mainly involving genes related to metabolism, DNA repair, cell apoptosis, etc. Recent genome-wide association studies are identifying novel susceptibility genes of breast cancer. These studies, without any biological hypothesis, provide us not only a promising prospect but also a big challenge in the GEI analysis. This review is aimed to present a summary of recent advances in the understanding of the contribution of the GEI to breast cancer, and thus implicate further research in the area.

Original languageEnglish
Pages (from-to)558-564
Number of pages7
JournalTumor
Volume31
Issue number6
DOIs
StatePublished - 1 Jun 2011

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Gene-Environment Interaction
Breast Neoplasms
Research
Genes
Genome-Wide Association Study
DNA Repair
Apoptosis
Neoplasms

Keywords

  • Breast neoplasms
  • Gene-environment interaction
  • Risk factors

Cite this

Jiang, Jun Yi ; Xiang, Yong Bing ; Tao, Meng Hua ; Xu, Wang Hong. / Advances in research of gene-environment interactions in breast cancer. In: Tumor. 2011 ; Vol. 31, No. 6. pp. 558-564.
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Advances in research of gene-environment interactions in breast cancer. / Jiang, Jun Yi; Xiang, Yong Bing; Tao, Meng Hua; Xu, Wang Hong.

In: Tumor, Vol. 31, No. 6, 01.06.2011, p. 558-564.

Research output: Contribution to journalReview article

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