Abstract
Breast cancer is one of the most frequently diagnosed cancers in women. It has been increasingly recognized that breast cancer is a result of interplays between different exposures and host susceptibilities. The study of gene-environment interactions (GEI) has been confined to candidate gene approach which is mainly involving genes related to metabolism, DNA repair, cell apoptosis, etc. Recent genome-wide association studies are identifying novel susceptibility genes of breast cancer. These studies, without any biological hypothesis, provide us not only a promising prospect but also a big challenge in the GEI analysis. This review is aimed to present a summary of recent advances in the understanding of the contribution of the GEI to breast cancer, and thus implicate further research in the area.
Original language | English |
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Pages (from-to) | 558-564 |
Number of pages | 7 |
Journal | Tumor |
Volume | 31 |
Issue number | 6 |
DOIs | |
State | Published - 1 Jun 2011 |
Keywords
- Breast neoplasms
- Gene-environment interaction
- Risk factors