ADME and ocular therapeutics: Retina

Cornelis J. Van Der Schyf, Samuel D. Crish, Christine Crish, Denise Inman, Werner J. Geldenhuys

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Ocular diseases such as glaucoma and macular degeneration can greatly impact the quality of patients' lives, with the possibility of loss of vision. The development of orally available drugs that can reach the posterior segment of the eye is hampered by the anatomy of the eye. In this chapter, we describe methods for obtaining and analyzing retina and associated optic tract structures for drug levels. These techniques can be used in drug development paradigms as well as for regulatory approval processes.

Original languageEnglish
Title of host publicationOcular Pharmacology and Toxicology
EditorsBrian Gilger
Number of pages9
StatePublished - 16 Jan 2014

Publication series

NameMethods in Pharmacology and Toxicology
ISSN (Print)1557-2153
ISSN (Electronic)1940-6053


  • ADME
  • Drug analysis
  • Glaucoma
  • Macular degeneration
  • Ocular therapeutics
  • Optic nerve
  • Retina
  • Superior colliculus
  • Tissue harvesting
  • Transporters


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