ADME and ocular therapeutics: Retina

Cornelis J. Van Der Schyf, Samuel D. Crish, Christine Crish, Denise Maureen Inman, Werner J. Geldenhuys

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Ocular diseases such as glaucoma and macular degeneration can greatly impact the quality of patients' lives, with the possibility of loss of vision. The development of orally available drugs that can reach the posterior segment of the eye is hampered by the anatomy of the eye. In this chapter, we describe methods for obtaining and analyzing retina and associated optic tract structures for drug levels. These techniques can be used in drug development paradigms as well as for regulatory approval processes.

Original languageEnglish
Title of host publicationOcular Pharmacology and Toxicology
EditorsBrian Gilger
Pages81-89
Number of pages9
DOIs
StatePublished - 16 Jan 2014

Publication series

NameMethods in Pharmacology and Toxicology
ISSN (Print)1557-2153
ISSN (Electronic)1940-6053

Fingerprint

Retina
Posterior Eye Segment
Pharmaceutical Preparations
Eye Diseases
Macular Degeneration
Glaucoma
Anatomy
Therapeutics
Optic Tract

Keywords

  • ADME
  • Drug analysis
  • Glaucoma
  • Macular degeneration
  • Ocular therapeutics
  • Optic nerve
  • Retina
  • Superior colliculus
  • Tissue harvesting
  • Transporters

Cite this

Van Der Schyf, C. J., Crish, S. D., Crish, C., Inman, D. M., & Geldenhuys, W. J. (2014). ADME and ocular therapeutics: Retina. In B. Gilger (Ed.), Ocular Pharmacology and Toxicology (pp. 81-89). (Methods in Pharmacology and Toxicology). https://doi.org/10.1007/7653-2013-12
Van Der Schyf, Cornelis J. ; Crish, Samuel D. ; Crish, Christine ; Inman, Denise Maureen ; Geldenhuys, Werner J. / ADME and ocular therapeutics : Retina. Ocular Pharmacology and Toxicology. editor / Brian Gilger. 2014. pp. 81-89 (Methods in Pharmacology and Toxicology).
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keywords = "ADME, Drug analysis, Glaucoma, Macular degeneration, Ocular therapeutics, Optic nerve, Retina, Superior colliculus, Tissue harvesting, Transporters",
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Van Der Schyf, CJ, Crish, SD, Crish, C, Inman, DM & Geldenhuys, WJ 2014, ADME and ocular therapeutics: Retina. in B Gilger (ed.), Ocular Pharmacology and Toxicology. Methods in Pharmacology and Toxicology, pp. 81-89. https://doi.org/10.1007/7653-2013-12

ADME and ocular therapeutics : Retina. / Van Der Schyf, Cornelis J.; Crish, Samuel D.; Crish, Christine; Inman, Denise Maureen; Geldenhuys, Werner J.

Ocular Pharmacology and Toxicology. ed. / Brian Gilger. 2014. p. 81-89 (Methods in Pharmacology and Toxicology).

Research output: Chapter in Book/Report/Conference proceedingChapter

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AU - Geldenhuys, Werner J.

PY - 2014/1/16

Y1 - 2014/1/16

N2 - Ocular diseases such as glaucoma and macular degeneration can greatly impact the quality of patients' lives, with the possibility of loss of vision. The development of orally available drugs that can reach the posterior segment of the eye is hampered by the anatomy of the eye. In this chapter, we describe methods for obtaining and analyzing retina and associated optic tract structures for drug levels. These techniques can be used in drug development paradigms as well as for regulatory approval processes.

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KW - Drug analysis

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KW - Macular degeneration

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A2 - Gilger, Brian

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Van Der Schyf CJ, Crish SD, Crish C, Inman DM, Geldenhuys WJ. ADME and ocular therapeutics: Retina. In Gilger B, editor, Ocular Pharmacology and Toxicology. 2014. p. 81-89. (Methods in Pharmacology and Toxicology). https://doi.org/10.1007/7653-2013-12