TY - JOUR
T1 - Adipose tissue-derived stem cells
T2 - Immunomodulatory effects and therapeutic potential
AU - Al-Ghadban, Sara
AU - Bunnell, Bruce A.
N1 - Funding Information:
The work was funded by the Lipedema foundation. No conflicts of interest, financial or otherwise, are declared by the author(s).
Publisher Copyright:
© 2020 Int. Union Physiol. Sci./Am. Physiol. Soc.
PY - 2020
Y1 - 2020
N2 - Adipose-derived stem cells (ASCs) can self-renew and differentiate along multiple cell lineages. ASCs are also potently anti-inflammatory due to their inherent ability to regulate the immune system by secreting anti-inflammatory cytokines and growth factors that play a crucial role in the pathology of many diseases, including multiple sclerosis, diabetes mellitus, Crohn’s, SLE, and graft-versus-host disease. The immunomodulatory effects and mechanisms of action of ASCs on pathological conditions are reviewed here.
AB - Adipose-derived stem cells (ASCs) can self-renew and differentiate along multiple cell lineages. ASCs are also potently anti-inflammatory due to their inherent ability to regulate the immune system by secreting anti-inflammatory cytokines and growth factors that play a crucial role in the pathology of many diseases, including multiple sclerosis, diabetes mellitus, Crohn’s, SLE, and graft-versus-host disease. The immunomodulatory effects and mechanisms of action of ASCs on pathological conditions are reviewed here.
KW - Adipose-derived stem cells
KW - Cytokines
KW - Immune cells
KW - Immunological disease
KW - Mechanisms of action
KW - Stromal vascular fraction
UR - http://www.scopus.com/inward/record.url?scp=85079082378&partnerID=8YFLogxK
U2 - 10.1152/physiol.00021.2019
DO - 10.1152/physiol.00021.2019
M3 - Review article
C2 - 32027561
AN - SCOPUS:85079082378
SN - 1548-9213
VL - 35
SP - 125
EP - 133
JO - Physiology
JF - Physiology
IS - 2
ER -