Adipose tissue-derived stem cells: Immunomodulatory effects and therapeutic potential

Sara Al-Ghadban, Bruce A. Bunnell

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

Adipose-derived stem cells (ASCs) can self-renew and differentiate along multiple cell lineages. ASCs are also potently anti-inflammatory due to their inherent ability to regulate the immune system by secreting anti-inflammatory cytokines and growth factors that play a crucial role in the pathology of many diseases, including multiple sclerosis, diabetes mellitus, Crohn’s, SLE, and graft-versus-host disease. The immunomodulatory effects and mechanisms of action of ASCs on pathological conditions are reviewed here.

Original languageEnglish
Pages (from-to)125-133
Number of pages9
JournalPhysiology
Volume35
Issue number2
DOIs
StatePublished - 2020

Keywords

  • Adipose-derived stem cells
  • Cytokines
  • Immune cells
  • Immunological disease
  • Mechanisms of action
  • Stromal vascular fraction

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