TY - JOUR
T1 - Adipose-Derived Stromal/Stem Cell Response to Tumors and Wounds
T2 - Evaluation of Patient Age
AU - Hamel, Katie M.
AU - Liimatta, Kara Q.
AU - Belgodere, Jorge A.
AU - Bunnell, Bruce A.
AU - Gimble, Jeffrey M.
AU - Martin, Elizabeth C.
N1 - Funding Information:
This publication was supported by U54 GM104940 from the National Institute of General Medical Sciences of the National Institutes of Health, which funds the Louisiana Clinical and Translational Science Center.
Publisher Copyright:
© 2022 Mary Ann Liebert, Inc., publishers.
PY - 2022/10/1
Y1 - 2022/10/1
N2 - Tumors were characterized as nonhealing wounds by Virchow in 1858 and Dvorak in 1986. Since then, researchers have analyzed tumors from a new perspective. The parallels between tumorigenesis and physiological wound healing can provide a new framework for developing antitumor therapeutics. One commonality between tumors and wounds is the involvement of the stromal environment, particularly adipose stromal/stem cells (ASCs). ASCs exhibit dual functions, in which they stimulate tumor progression and assist in tissue repair and regeneration. Numerous studies have focused on the role of ASCs in cancer and wound healing, but none to date has linked age, cancer, and wound healing. Furthermore, very few studies have focused on the role of donor-specific characteristics of ASCs, such as age and their role in facilitating ASC behavior in cancer and wound healing. This review article is designed to provide important insights into the impact of donor age on ASC tumor and wound response and their role in facilitating ASC behavior in cancer and wound healing.
AB - Tumors were characterized as nonhealing wounds by Virchow in 1858 and Dvorak in 1986. Since then, researchers have analyzed tumors from a new perspective. The parallels between tumorigenesis and physiological wound healing can provide a new framework for developing antitumor therapeutics. One commonality between tumors and wounds is the involvement of the stromal environment, particularly adipose stromal/stem cells (ASCs). ASCs exhibit dual functions, in which they stimulate tumor progression and assist in tissue repair and regeneration. Numerous studies have focused on the role of ASCs in cancer and wound healing, but none to date has linked age, cancer, and wound healing. Furthermore, very few studies have focused on the role of donor-specific characteristics of ASCs, such as age and their role in facilitating ASC behavior in cancer and wound healing. This review article is designed to provide important insights into the impact of donor age on ASC tumor and wound response and their role in facilitating ASC behavior in cancer and wound healing.
KW - adipose-derived stromal/stem cells (ASCs)
KW - keloid scars
KW - tumor microenvironment (TME)
KW - wound healing
UR - http://www.scopus.com/inward/record.url?scp=85140416898&partnerID=8YFLogxK
U2 - 10.1089/scd.2021.0280
DO - 10.1089/scd.2021.0280
M3 - Review article
C2 - 35262397
AN - SCOPUS:85140416898
SN - 1547-3287
VL - 31
SP - 579
EP - 592
JO - Stem Cells and Development
JF - Stem Cells and Development
IS - 19-20
ER -