TY - JOUR
T1 - Adiponectin
T2 - Its role in obesity-associated colon and prostate cancers
AU - Muppala, Santoshi
AU - Konduru, Siva K.P.
AU - Merchant, Neha
AU - Ramsoondar, Judy
AU - Rampersad, Carlos Karan
AU - Rajitha, Balney
AU - Mukund, Vidya
AU - Kancherla, Jyothsna
AU - Hammond, Anthea
AU - Barik, Tapan Kumar
AU - Mannarapu, Mastan
AU - Alam, Afroz
AU - Basha, Riyaz
AU - Bramhachari, Pallaval Veera
AU - Verma, Dheeraj
AU - Sushma, Pinninti Santosh
AU - Pattnaik, Subasini
AU - Nagaraju, Ganji Purnachandra
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Adipose tissue synthesizes many proteins and hormones collectively called adipokines, which are linked to a number of diseases, including cancer. Low levels of adiponectin are reported to be a risk factor for obesity-related cancers including colorectal and prostate cancers. Accordingly, obesity/lifestyle-related diseases, including certain cancers, may be treated by developing drugs that act specifically on adiponectin levels in circulation. Adiponectin may also serve as a clinical biomarker in obesity-related diseases. Adiponectin-based therapies are known to inhibit cancer advancement and thus may provide a therapeutic approach to delay cancer progression. Better understanding of the function of adiponectin is of great significance in the fight against cancer. This timely review is concentrated on the role of adiponectin and the impact of obesity on the development of cancers, especially colorectal and prostate cancers.
AB - Adipose tissue synthesizes many proteins and hormones collectively called adipokines, which are linked to a number of diseases, including cancer. Low levels of adiponectin are reported to be a risk factor for obesity-related cancers including colorectal and prostate cancers. Accordingly, obesity/lifestyle-related diseases, including certain cancers, may be treated by developing drugs that act specifically on adiponectin levels in circulation. Adiponectin may also serve as a clinical biomarker in obesity-related diseases. Adiponectin-based therapies are known to inhibit cancer advancement and thus may provide a therapeutic approach to delay cancer progression. Better understanding of the function of adiponectin is of great significance in the fight against cancer. This timely review is concentrated on the role of adiponectin and the impact of obesity on the development of cancers, especially colorectal and prostate cancers.
KW - Adiponectin
KW - Adiponectin receptors
KW - Colorectal cancer
KW - Obesity
KW - Prostate cancer
UR - http://www.scopus.com/inward/record.url?scp=85024849369&partnerID=8YFLogxK
U2 - 10.1016/j.critrevonc.2017.06.003
DO - 10.1016/j.critrevonc.2017.06.003
M3 - Review article
C2 - 28693794
AN - SCOPUS:85024849369
SN - 1040-8428
VL - 116
SP - 125
EP - 133
JO - Critical Reviews in Oncology/Hematology
JF - Critical Reviews in Oncology/Hematology
ER -