Acute tobacco smoke exposure alters the profile of metabolites produced from benzo[a]pyrene by the isolated perfused rabbit lung

William Charles Lubawy, R. S. Isaac

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The influence of whole tobacco smoke or the gas phase from smoke on the metabolism of [14C]benzo[a]pyrene was e xamined using the isolated perfused rabbit lung model. Fresh whole tobacco smoke mixed with the air ventilating the perfused lung produces an immediate and dose related decrease in the metabolism of [14C]benzo[a]pyrene. The metabolites of [14C]benzo[a]pyrene, diols, quinones, phenols and polar compounds are generally decreased in quantity. At the lowest level of smoke administered the percentage of BP-7,8-diol produced is increased dramatically. The results indicate that one of the factors contributing to the carcinogenicity of tobacco smoke may be its ability to produce an immediate alteration in the pulmonary metabolism of polycyclic aromatic hydrocarbons.

Original languageEnglish
Pages (from-to)37-47
Number of pages11
JournalToxicology
Volume18
Issue number1
DOIs
StatePublished - 1 Jan 1980

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Tobacco
Benzo(a)pyrene
Metabolites
Smoke
Rabbits
Lung
Metabolism
Quinones
Phenols
Polycyclic Aromatic Hydrocarbons
Gases
Air

Cite this

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Acute tobacco smoke exposure alters the profile of metabolites produced from benzo[a]pyrene by the isolated perfused rabbit lung. / Lubawy, William Charles; Isaac, R. S.

In: Toxicology, Vol. 18, No. 1, 01.01.1980, p. 37-47.

Research output: Contribution to journalArticle

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