Acute Mycoplasma pulmonis infection associated with coagulopathy in C3H/HeN mice

C. B. Faulkner, M. K. Davidson, J. K. Davis, T. R. Schoeb, Jerry Simecka, J. R. Lindsey

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6 Scopus citations


Experimentally induced infection with high doses of Mycoplasma pulmonis results in acute pneumonia characterized by severe pulmonary hemorrhage, edema, and, often, death in C3H/HeN mice. To determine whether specific disease manifestations were associated with coagulopathy, we measured serum fibrin, fibrinogen degradation products, and plasma fibrinogen concentrations in C3H/HeN mice infected with high doses of a virulent strain of M. pulmonis. We also examined the lungs and other tissues from infected mice for the presence of intravascular fibrin clots and other lesions. Increased concentrations of fibrinogen degradation products indicated that coagulopathy occurs in acute M. pulmonis infection; however, intravascular fibrin clots were not present. Rather than decreasing, as might be expected during a consumptive coagulopathy, fibrinogen concentrations increased. The hyperfibrinogenemia probably is associated with an acute phase response to M. pulmonis infection.

Original languageEnglish
Pages (from-to)368-372
Number of pages5
JournalLaboratory Animal Science
Issue number4
StatePublished - 1 Jan 1995


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